IL37 protein (Nomascus leucogenys) - STRING interaction network

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Score

IL37

Interleukin-1. (218 aa)

Predicted Functional Partners:

IL18R1

0.993

IL18RAP

0.960

SMAD3

0.957

IL18

0.928

IL18BP

0.870

CASP1

0.828

IL1R1

0.690

IL1B

0.675

IL1RL2

0.671

SMAD2

0.617

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	IL18	ENSNLEP00000044525	ENSNLEP00000038207	Caspase 1; Belongs to the peptidase C14A family.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.984
CASP1	IL18BP	ENSNLEP00000044525	ENSNLEP00000020962	Caspase 1; Belongs to the peptidase C14A family.	Interleukin 18 binding protein.	0.446
CASP1	IL1B	ENSNLEP00000044525	ENSNLEP00000044905	Caspase 1; Belongs to the peptidase C14A family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.998
CASP1	IL1R1	ENSNLEP00000044525	ENSNLEP00000023655	Caspase 1; Belongs to the peptidase C14A family.	Interleukin 1 receptor type 1.	0.685
CASP1	IL37	ENSNLEP00000044525	ENSNLEP00000002345	Caspase 1; Belongs to the peptidase C14A family.	Interleukin-1.	0.828
CASP1	SMAD3	ENSNLEP00000044525	ENSNLEP00000041430	Caspase 1; Belongs to the peptidase C14A family.	Mothers against decapentaplegic homolog.	0.445
IL18	CASP1	ENSNLEP00000038207	ENSNLEP00000044525	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Caspase 1; Belongs to the peptidase C14A family.	0.984
IL18	IL18BP	ENSNLEP00000038207	ENSNLEP00000020962	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 binding protein.	0.779
IL18	IL18R1	ENSNLEP00000038207	ENSNLEP00000017837	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 receptor 1.	0.985
IL18	IL18RAP	ENSNLEP00000038207	ENSNLEP00000017859	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 receptor accessory protein.	0.984
IL18	IL1B	ENSNLEP00000038207	ENSNLEP00000044905	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.684
IL18	IL37	ENSNLEP00000038207	ENSNLEP00000002345	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-1.	0.928
IL18BP	CASP1	ENSNLEP00000020962	ENSNLEP00000044525	Interleukin 18 binding protein.	Caspase 1; Belongs to the peptidase C14A family.	0.446
IL18BP	IL18	ENSNLEP00000020962	ENSNLEP00000038207	Interleukin 18 binding protein.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.779
IL18BP	IL18R1	ENSNLEP00000020962	ENSNLEP00000017837	Interleukin 18 binding protein.	Interleukin 18 receptor 1.	0.758
IL18BP	IL18RAP	ENSNLEP00000020962	ENSNLEP00000017859	Interleukin 18 binding protein.	Interleukin 18 receptor accessory protein.	0.704
IL18BP	IL1B	ENSNLEP00000020962	ENSNLEP00000044905	Interleukin 18 binding protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.456
IL18BP	IL37	ENSNLEP00000020962	ENSNLEP00000002345	Interleukin 18 binding protein.	Interleukin-1.	0.870
IL18R1	IL18	ENSNLEP00000017837	ENSNLEP00000038207	Interleukin 18 receptor 1.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.985
IL18R1	IL18BP	ENSNLEP00000017837	ENSNLEP00000020962	Interleukin 18 receptor 1.	Interleukin 18 binding protein.	0.758

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