| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HGS | MVB12A | ENSNLEP00000016808 | ENSNLEP00000006998 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Multivesicular body subunit 12A. | 0.834 |
| HGS | MVB12B | ENSNLEP00000016808 | ENSNLEP00000042285 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Multivesicular body subunit 12B. | 0.813 |
| HGS | SNF8 | ENSNLEP00000016808 | ENSNLEP00000003338 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | 0.872 |
| HGS | STAM | ENSNLEP00000016808 | ENSNLEP00000046424 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Signal transducing adaptor molecule. | 0.999 |
| HGS | TSG101 | ENSNLEP00000016808 | ENSNLEP00000021594 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Tumor susceptibility 101. | 0.998 |
| HGS | VPS25 | ENSNLEP00000016808 | ENSNLEP00000014357 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Vacuolar protein sorting 25 homolog. | 0.873 |
| HGS | VPS28 | ENSNLEP00000016808 | ENSNLEP00000013013 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | VPS28 N-terminal domain-containing protein; Belongs to the VPS28 family. | 0.969 |
| HGS | VPS36 | ENSNLEP00000016808 | ENSNLEP00000019132 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Vacuolar protein sorting 36 homolog. | 0.881 |
| HGS | VPS37A | ENSNLEP00000016808 | ENSNLEP00000034729 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | VPS37A subunit of ESCRT-I. | 0.899 |
| HGS | VPS37B | ENSNLEP00000016808 | ENSNLEP00000002726 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | VPS37B subunit of ESCRT-I. | 0.869 |
| MVB12A | HGS | ENSNLEP00000006998 | ENSNLEP00000016808 | Multivesicular body subunit 12A. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.834 |
| MVB12A | MVB12B | ENSNLEP00000006998 | ENSNLEP00000042285 | Multivesicular body subunit 12A. | Multivesicular body subunit 12B. | 0.939 |
| MVB12A | SNF8 | ENSNLEP00000006998 | ENSNLEP00000003338 | Multivesicular body subunit 12A. | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | 0.872 |
| MVB12A | STAM | ENSNLEP00000006998 | ENSNLEP00000046424 | Multivesicular body subunit 12A. | Signal transducing adaptor molecule. | 0.884 |
| MVB12A | TSG101 | ENSNLEP00000006998 | ENSNLEP00000021594 | Multivesicular body subunit 12A. | Tumor susceptibility 101. | 0.987 |
| MVB12A | VPS25 | ENSNLEP00000006998 | ENSNLEP00000014357 | Multivesicular body subunit 12A. | Vacuolar protein sorting 25 homolog. | 0.940 |
| MVB12A | VPS28 | ENSNLEP00000006998 | ENSNLEP00000013013 | Multivesicular body subunit 12A. | VPS28 N-terminal domain-containing protein; Belongs to the VPS28 family. | 0.993 |
| MVB12A | VPS36 | ENSNLEP00000006998 | ENSNLEP00000019132 | Multivesicular body subunit 12A. | Vacuolar protein sorting 36 homolog. | 0.853 |
| MVB12A | VPS37A | ENSNLEP00000006998 | ENSNLEP00000034729 | Multivesicular body subunit 12A. | VPS37A subunit of ESCRT-I. | 0.965 |
| MVB12A | VPS37B | ENSNLEP00000006998 | ENSNLEP00000002726 | Multivesicular body subunit 12A. | VPS37B subunit of ESCRT-I. | 0.994 |
