| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADIPOQ | FGF21 | ENSNLEP00000008120 | ENSNLEP00000005639 | Adiponectin, C1Q and collagen domain containing. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.591 |
| ADIPOQ | FNDC5 | ENSNLEP00000008120 | ENSNLEP00000003686 | Adiponectin, C1Q and collagen domain containing. | Fibronectin type III domain containing 5. | 0.485 |
| ADIPOQ | LEP | ENSNLEP00000008120 | ENSNLEP00000014938 | Adiponectin, C1Q and collagen domain containing. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.930 |
| ADIPOQ | PPARGC1A | ENSNLEP00000008120 | ENSNLEP00000041737 | Adiponectin, C1Q and collagen domain containing. | PPARG coactivator 1 alpha. | 0.771 |
| ADIPOQ | UCP1 | ENSNLEP00000008120 | ENSNLEP00000006269 | Adiponectin, C1Q and collagen domain containing. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.705 |
| BDNF | FNDC5 | ENSNLEP00000021698 | ENSNLEP00000003686 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Fibronectin type III domain containing 5. | 0.485 |
| BDNF | LEP | ENSNLEP00000021698 | ENSNLEP00000014938 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.552 |
| BDNF | METRN | ENSNLEP00000021698 | ENSNLEP00000036377 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Uncharacterized protein. | 0.453 |
| BDNF | PPARGC1A | ENSNLEP00000021698 | ENSNLEP00000041737 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | PPARG coactivator 1 alpha. | 0.452 |
| FGF21 | ADIPOQ | ENSNLEP00000005639 | ENSNLEP00000008120 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Adiponectin, C1Q and collagen domain containing. | 0.591 |
| FGF21 | FNDC5 | ENSNLEP00000005639 | ENSNLEP00000003686 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibronectin type III domain containing 5. | 0.587 |
| FGF21 | LEP | ENSNLEP00000005639 | ENSNLEP00000014938 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.537 |
| FGF21 | MSTN | ENSNLEP00000005639 | ENSNLEP00000008080 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Myostatin. | 0.439 |
| FGF21 | PPARGC1A | ENSNLEP00000005639 | ENSNLEP00000041737 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | PPARG coactivator 1 alpha. | 0.596 |
| FGF21 | UCP1 | ENSNLEP00000005639 | ENSNLEP00000006269 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.598 |
| FNDC5 | ADIPOQ | ENSNLEP00000003686 | ENSNLEP00000008120 | Fibronectin type III domain containing 5. | Adiponectin, C1Q and collagen domain containing. | 0.485 |
| FNDC5 | BDNF | ENSNLEP00000003686 | ENSNLEP00000021698 | Fibronectin type III domain containing 5. | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | 0.485 |
| FNDC5 | FGF21 | ENSNLEP00000003686 | ENSNLEP00000005639 | Fibronectin type III domain containing 5. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.587 |
| FNDC5 | LEP | ENSNLEP00000003686 | ENSNLEP00000014938 | Fibronectin type III domain containing 5. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.482 |
| FNDC5 | METRN | ENSNLEP00000003686 | ENSNLEP00000036377 | Fibronectin type III domain containing 5. | Uncharacterized protein. | 0.502 |