NUMB protein (Nomascus leucogenys) - STRING interaction network

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Score

NUMB

NUMB endocytic adaptor protein. (650 aa)

Predicted Functional Partners:

ITCH

0.976

DPYSL2

0.967

LNX1

0.933

NOTCH1

0.815

AP2A1

0.808

EPS15

0.792

LOC101176233

0.792

LNX2

0.748

GAK

0.712

MSI2

0.707

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2A1	EPS15	ENSNLEP00000006457	ENSNLEP00000044546	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Epidermal growth factor receptor pathway substrate 15.	0.938
AP2A1	GAK	ENSNLEP00000006457	ENSNLEP00000001124	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Cyclin G associated kinase.	0.964
AP2A1	LOC101176233	ENSNLEP00000006457	ENSNLEP00000047166	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Uncharacterized protein.	0.938
AP2A1	NUMB	ENSNLEP00000006457	ENSNLEP00000003700	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	NUMB endocytic adaptor protein.	0.808
DPYSL2	NUMB	ENSNLEP00000019731	ENSNLEP00000003700	Dihydropyrimidinase like 2.	NUMB endocytic adaptor protein.	0.967
EPS15	AP2A1	ENSNLEP00000044546	ENSNLEP00000006457	Epidermal growth factor receptor pathway substrate 15.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.938
EPS15	GAK	ENSNLEP00000044546	ENSNLEP00000001124	Epidermal growth factor receptor pathway substrate 15.	Cyclin G associated kinase.	0.814
EPS15	NUMB	ENSNLEP00000044546	ENSNLEP00000003700	Epidermal growth factor receptor pathway substrate 15.	NUMB endocytic adaptor protein.	0.792
GAK	AP2A1	ENSNLEP00000001124	ENSNLEP00000006457	Cyclin G associated kinase.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.964
GAK	EPS15	ENSNLEP00000001124	ENSNLEP00000044546	Cyclin G associated kinase.	Epidermal growth factor receptor pathway substrate 15.	0.814
GAK	LOC101176233	ENSNLEP00000001124	ENSNLEP00000047166	Cyclin G associated kinase.	Uncharacterized protein.	0.814
GAK	NUMB	ENSNLEP00000001124	ENSNLEP00000003700	Cyclin G associated kinase.	NUMB endocytic adaptor protein.	0.712
ITCH	NOTCH1	ENSNLEP00000044707	ENSNLEP00000010158	E3 ubiquitin-protein ligase.	Notch receptor 1.	0.487
ITCH	NUMB	ENSNLEP00000044707	ENSNLEP00000003700	E3 ubiquitin-protein ligase.	NUMB endocytic adaptor protein.	0.976
LNX1	NUMB	ENSNLEP00000010063	ENSNLEP00000003700	Ligand of numb-protein X 1.	NUMB endocytic adaptor protein.	0.933
LNX2	NUMB	ENSNLEP00000000418	ENSNLEP00000003700	Ligand of numb-protein X 2.	NUMB endocytic adaptor protein.	0.748
LOC101176233	AP2A1	ENSNLEP00000047166	ENSNLEP00000006457	Uncharacterized protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.938
LOC101176233	GAK	ENSNLEP00000047166	ENSNLEP00000001124	Uncharacterized protein.	Cyclin G associated kinase.	0.814
LOC101176233	NUMB	ENSNLEP00000047166	ENSNLEP00000003700	Uncharacterized protein.	NUMB endocytic adaptor protein.	0.792
MSI2	NUMB	ENSNLEP00000009843	ENSNLEP00000003700	Musashi RNA binding protein 2.	NUMB endocytic adaptor protein.	0.707

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