| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATM | DYRK4 | ENSNLEP00000008823 | ENSNLEP00000003907 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Dual specificity tyrosine phosphorylation regulated kinase 4. | 0.586 |
| ATM | G1R9J5_NOMLE | ENSNLEP00000008823 | ENSNLEP00000009887 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | SAM domain-containing protein. | 0.829 |
| ATM | KCTD2 | ENSNLEP00000008823 | ENSNLEP00000000637 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Uncharacterized protein. | 0.515 |
| ATM | MDM2 | ENSNLEP00000008823 | ENSNLEP00000037842 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | MDM2 proto-oncogene. | 0.842 |
| ATM | MDM4 | ENSNLEP00000008823 | ENSNLEP00000023664 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.872 |
| ATM | TP63 | ENSNLEP00000008823 | ENSNLEP00000032932 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.829 |
| ATM | UBE2I | ENSNLEP00000008823 | ENSNLEP00000010420 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.696 |
| DCAF7 | DYRK4 | ENSNLEP00000005405 | ENSNLEP00000003907 | DDB1 and CUL4 associated factor 7. | Dual specificity tyrosine phosphorylation regulated kinase 4. | 0.761 |
| DYRK4 | ATM | ENSNLEP00000003907 | ENSNLEP00000008823 | Dual specificity tyrosine phosphorylation regulated kinase 4. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.586 |
| DYRK4 | DCAF7 | ENSNLEP00000003907 | ENSNLEP00000005405 | Dual specificity tyrosine phosphorylation regulated kinase 4. | DDB1 and CUL4 associated factor 7. | 0.761 |
| DYRK4 | G1R9J5_NOMLE | ENSNLEP00000003907 | ENSNLEP00000009887 | Dual specificity tyrosine phosphorylation regulated kinase 4. | SAM domain-containing protein. | 0.406 |
| DYRK4 | KCTD2 | ENSNLEP00000003907 | ENSNLEP00000000637 | Dual specificity tyrosine phosphorylation regulated kinase 4. | Uncharacterized protein. | 0.411 |
| DYRK4 | LIN52 | ENSNLEP00000003907 | ENSNLEP00000019647 | Dual specificity tyrosine phosphorylation regulated kinase 4. | Lin-52 DREAM MuvB core complex component. | 0.425 |
| DYRK4 | MDM2 | ENSNLEP00000003907 | ENSNLEP00000037842 | Dual specificity tyrosine phosphorylation regulated kinase 4. | MDM2 proto-oncogene. | 0.424 |
| DYRK4 | MDM4 | ENSNLEP00000003907 | ENSNLEP00000023664 | Dual specificity tyrosine phosphorylation regulated kinase 4. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.529 |
| DYRK4 | SLC13A5 | ENSNLEP00000003907 | ENSNLEP00000025806 | Dual specificity tyrosine phosphorylation regulated kinase 4. | Solute carrier family 13 member 5. | 0.453 |
| DYRK4 | TP63 | ENSNLEP00000003907 | ENSNLEP00000032932 | Dual specificity tyrosine phosphorylation regulated kinase 4. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.406 |
| DYRK4 | UBE2I | ENSNLEP00000003907 | ENSNLEP00000010420 | Dual specificity tyrosine phosphorylation regulated kinase 4. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.411 |
| G1R9J5_NOMLE | ATM | ENSNLEP00000009887 | ENSNLEP00000008823 | SAM domain-containing protein. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.829 |
| G1R9J5_NOMLE | DYRK4 | ENSNLEP00000009887 | ENSNLEP00000003907 | SAM domain-containing protein. | Dual specificity tyrosine phosphorylation regulated kinase 4. | 0.406 |
STRING v12.5 is now available!
