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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)    
Predicted Functional Partners:
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.999
CDKN1B
Uncharacterized protein.
   
 0.997
RB1
RB transcriptional corepressor 1.
   
 0.981
CDC25A
Cell division cycle 25A.
   
 0.978
RBL2
RB transcriptional corepressor like 2.
   
 0.977
RBL1
RB transcriptional corepressor like 1.
   
 0.977
CDK4
Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.977
CUL1
Cullin 1; Belongs to the cullin family.
    
 0.973
SKP2
S-phase kinase associated protein 2.
   
 0.973
CCND1
Cyclin D1; Belongs to the cyclin family.
   
0.963
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.