| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRCA1 | RNF8 | ENSNLEP00000042201 | ENSNLEP00000013584 | BRCA1 DNA repair associated. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.745 |
| BRCA1 | UBE2E1 | ENSNLEP00000042201 | ENSNLEP00000004310 | BRCA1 DNA repair associated. | Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. | 0.848 |
| BRCA1 | UBE2E2 | ENSNLEP00000042201 | ENSNLEP00000004290 | BRCA1 DNA repair associated. | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. | 0.821 |
| BRCA1 | UBE2E3 | ENSNLEP00000042201 | ENSNLEP00000007645 | BRCA1 DNA repair associated. | Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. | 0.845 |
| ENSNLEP00000049227 | PRKN | ENSNLEP00000049227 | ENSNLEP00000013941 | Uncharacterized protein. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.755 |
| ENSNLEP00000049227 | RNF8 | ENSNLEP00000049227 | ENSNLEP00000013584 | Uncharacterized protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.718 |
| ENSNLEP00000049227 | TRIP12 | ENSNLEP00000049227 | ENSNLEP00000016601 | Uncharacterized protein. | Thyroid hormone receptor interactor 12. | 0.521 |
| ENSNLEP00000049227 | UBA1 | ENSNLEP00000049227 | ENSNLEP00000003842 | Uncharacterized protein. | Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | 0.718 |
| ENSNLEP00000049227 | UBE2E1 | ENSNLEP00000049227 | ENSNLEP00000004310 | Uncharacterized protein. | Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. | 0.845 |
| ENSNLEP00000049227 | UBE2E2 | ENSNLEP00000049227 | ENSNLEP00000004290 | Uncharacterized protein. | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. | 0.845 |
| ENSNLEP00000049227 | UBE2E3 | ENSNLEP00000049227 | ENSNLEP00000007645 | Uncharacterized protein. | Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. | 0.845 |
| HERC5 | PRKN | ENSNLEP00000011863 | ENSNLEP00000013941 | HECT and RLD domain containing E3 ubiquitin protein ligase 5. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.613 |
| HERC5 | TRIP12 | ENSNLEP00000011863 | ENSNLEP00000016601 | HECT and RLD domain containing E3 ubiquitin protein ligase 5. | Thyroid hormone receptor interactor 12. | 0.517 |
| HERC5 | UBA1 | ENSNLEP00000011863 | ENSNLEP00000003842 | HECT and RLD domain containing E3 ubiquitin protein ligase 5. | Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | 0.454 |
| HERC5 | UBE2E2 | ENSNLEP00000011863 | ENSNLEP00000004290 | HECT and RLD domain containing E3 ubiquitin protein ligase 5. | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. | 0.831 |
| HERC5 | UBE2E3 | ENSNLEP00000011863 | ENSNLEP00000007645 | HECT and RLD domain containing E3 ubiquitin protein ligase 5. | Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. | 0.650 |
| PRKN | ENSNLEP00000049227 | ENSNLEP00000013941 | ENSNLEP00000049227 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Uncharacterized protein. | 0.755 |
| PRKN | HERC5 | ENSNLEP00000013941 | ENSNLEP00000011863 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | HECT and RLD domain containing E3 ubiquitin protein ligase 5. | 0.613 |
| PRKN | UBE2E1 | ENSNLEP00000013941 | ENSNLEP00000004310 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. | 0.715 |
| PRKN | UBE2E2 | ENSNLEP00000013941 | ENSNLEP00000004290 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. | 0.877 |
