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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UBE2E2Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)    
Predicted Functional Partners:
RLIM
Ring finger protein, LIM domain interacting.
   
 0.933
UBE2E1
Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family.
  
  
0.933
PRKN
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.
    
 0.933
UBE2E3
Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family.
  
  
0.922
ENSNLEP00000049227
Uncharacterized protein.
   
 0.919
UBA1
Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.
  
 0.895
UBA7
Ubiquitin like modifier activating enzyme 7.
  
 0.837
TRIP12
Thyroid hormone receptor interactor 12.
   
 0.835
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
 0.774
ANAPC4
Anaphase promoting complex subunit 4.
   
 0.747
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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