STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)    
Predicted Functional Partners:
BRIP1
BRCA1 interacting protein C-terminal helicase 1.
   
 0.999
BRCA1
BRCA1 DNA repair associated.
   
 0.998
BARD1
BRCA1 associated RING domain 1.
   
 0.996
TICRR
TOPBP1 interacting checkpoint and replication regulator.
    
 
 0.991
RAD9A
Cell cycle checkpoint control protein; Belongs to the rad9 family.
    
 0.988
ATRIP
ATR interacting protein.
    
 0.986
RHNO1
RAD9-HUS1-RAD1 interacting nuclear orphan 1.
    
 0.978
CDC45
Cell division cycle 45.
   
 
 0.976
CLSPN
Claspin.
     
 0.970
CHEK1
Checkpoint kinase 1.
   
 0.968
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.