Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PDIA4Protein disulfide-isomerase. (615 aa)    
Predicted Functional Partners:
ERO1A
Endoplasmic reticulum oxidoreductase 1 alpha.
   
 0.978
ERO1B
Endoplasmic reticulum oxidoreductase 1 beta.
   
 0.978
CALR
Calreticulin.
   
 0.977
HSPA5
Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.
   
 0.973
ENSNLEP00000038312
Uncharacterized protein; Belongs to the heat shock protein 70 family.
   
 0.973
HSP90B1
Heat shock protein 90 beta family member 1.
   
 0.970
CALR3
Calreticulin.
   
 0.962
LOC100603153
Uncharacterized protein.
   
 0.961
PDIA3
Protein disulfide-isomerase.
   
   0.960
HYOU1
Hypoxia up-regulated 1.
   
 0.945
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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