STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1340 aa)    
Predicted Functional Partners:
NPC2
ML domain-containing protein.
   
 0.942
SREBF2
Sterol regulatory element binding transcription factor 2.
   
 0.835
SREBF1
Sterol regulatory element binding transcription factor 1.
   
 0.797
CYP7A1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
   
  
 0.739
MYCN
BHLH domain-containing protein.
   
 0.729
SCARB1
Scavenger receptor class B member 1; Belongs to the CD36 family.
   
  
 0.729
ABCG5
ATP binding cassette subfamily G member 5.
   
 
 0.707
ABCG8
ATP binding cassette subfamily G member 8.
   
 
 0.704
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
  
 0.696
APOB
Apolipoprotein B.
   
  
 0.690
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.