| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APRT | GMPR | ENSNLEP00000018947 | ENSNLEP00000001235 | Adenine phosphoribosyltransferase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.932 |
| APRT | GMPS | ENSNLEP00000018947 | ENSNLEP00000004717 | Adenine phosphoribosyltransferase. | Guanine monophosphate synthase. | 0.980 |
| APRT | GUK1 | ENSNLEP00000018947 | ENSNLEP00000048017 | Adenine phosphoribosyltransferase. | Guanylate kinase-like domain-containing protein. | 0.961 |
| APRT | HPRT1 | ENSNLEP00000018947 | ENSNLEP00000002427 | Adenine phosphoribosyltransferase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.971 |
| APRT | IMPDH2 | ENSNLEP00000018947 | ENSNLEP00000008217 | Adenine phosphoribosyltransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.527 |
| APRT | NT5C | ENSNLEP00000018947 | ENSNLEP00000000697 | Adenine phosphoribosyltransferase. | 5', 3'-nucleotidase, cytosolic. | 0.900 |
| APRT | NT5E | ENSNLEP00000018947 | ENSNLEP00000015555 | Adenine phosphoribosyltransferase. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.942 |
| GMPR | APRT | ENSNLEP00000001235 | ENSNLEP00000018947 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Adenine phosphoribosyltransferase. | 0.932 |
| GMPR | GMPS | ENSNLEP00000001235 | ENSNLEP00000004717 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Guanine monophosphate synthase. | 0.974 |
| GMPR | GUK1 | ENSNLEP00000001235 | ENSNLEP00000048017 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Guanylate kinase-like domain-containing protein. | 0.918 |
| GMPR | HPRT1 | ENSNLEP00000001235 | ENSNLEP00000002427 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.920 |
| GMPR | IMPDH2 | ENSNLEP00000001235 | ENSNLEP00000008217 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.913 |
| GMPR | LOC100581732 | ENSNLEP00000001235 | ENSNLEP00000040472 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.916 |
| GMPR | NT5C | ENSNLEP00000001235 | ENSNLEP00000000697 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 5', 3'-nucleotidase, cytosolic. | 0.924 |
| GMPR | NT5E | ENSNLEP00000001235 | ENSNLEP00000015555 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.951 |
| GMPS | APRT | ENSNLEP00000004717 | ENSNLEP00000018947 | Guanine monophosphate synthase. | Adenine phosphoribosyltransferase. | 0.980 |
| GMPS | GMPR | ENSNLEP00000004717 | ENSNLEP00000001235 | Guanine monophosphate synthase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.974 |
| GMPS | GUK1 | ENSNLEP00000004717 | ENSNLEP00000048017 | Guanine monophosphate synthase. | Guanylate kinase-like domain-containing protein. | 0.957 |
| GMPS | HPRT1 | ENSNLEP00000004717 | ENSNLEP00000002427 | Guanine monophosphate synthase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.932 |
| GMPS | IMPDH2 | ENSNLEP00000004717 | ENSNLEP00000008217 | Guanine monophosphate synthase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.985 |