NAE1 protein (Nomascus leucogenys) - STRING interaction network

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NAE1

NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (532 aa)

Predicted Functional Partners:

UBA3

0.999

UBE2M

0.997

APP

0.981

NEDD8

0.947

UBE2F

0.940

CUL1

0.849

RBX1

0.778

SENP8

0.774

MOCS2

0.772

DCUN1D1

0.770

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	CUL1	ENSNLEP00000026435	ENSNLEP00000004334	Amyloid beta precursor protein.	Cullin 1; Belongs to the cullin family.	0.441
APP	NAE1	ENSNLEP00000026435	ENSNLEP00000004923	Amyloid beta precursor protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.981
APP	UBA3	ENSNLEP00000026435	ENSNLEP00000002646	Amyloid beta precursor protein.	Ubiquitin like modifier activating enzyme 3.	0.487
CUL1	APP	ENSNLEP00000004334	ENSNLEP00000026435	Cullin 1; Belongs to the cullin family.	Amyloid beta precursor protein.	0.441
CUL1	DCUN1D1	ENSNLEP00000004334	ENSNLEP00000037729	Cullin 1; Belongs to the cullin family.	DCN1-like protein.	0.985
CUL1	NAE1	ENSNLEP00000004334	ENSNLEP00000004923	Cullin 1; Belongs to the cullin family.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.849
CUL1	NEDD8	ENSNLEP00000004334	ENSNLEP00000027144	Cullin 1; Belongs to the cullin family.	NEDD8 ubiquitin like modifier.	0.965
CUL1	RBX1	ENSNLEP00000004334	ENSNLEP00000036078	Cullin 1; Belongs to the cullin family.	Ring-box 1.	0.999
CUL1	SENP8	ENSNLEP00000004334	ENSNLEP00000027746	Cullin 1; Belongs to the cullin family.	SUMO peptidase family member, NEDD8 specific.	0.729
CUL1	UBA3	ENSNLEP00000004334	ENSNLEP00000002646	Cullin 1; Belongs to the cullin family.	Ubiquitin like modifier activating enzyme 3.	0.876
CUL1	UBE2F	ENSNLEP00000004334	ENSNLEP00000013582	Cullin 1; Belongs to the cullin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.899
CUL1	UBE2M	ENSNLEP00000004334	ENSNLEP00000013633	Cullin 1; Belongs to the cullin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.986
DCUN1D1	CUL1	ENSNLEP00000037729	ENSNLEP00000004334	DCN1-like protein.	Cullin 1; Belongs to the cullin family.	0.985
DCUN1D1	NAE1	ENSNLEP00000037729	ENSNLEP00000004923	DCN1-like protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.770
DCUN1D1	NEDD8	ENSNLEP00000037729	ENSNLEP00000027144	DCN1-like protein.	NEDD8 ubiquitin like modifier.	0.853
DCUN1D1	RBX1	ENSNLEP00000037729	ENSNLEP00000036078	DCN1-like protein.	Ring-box 1.	0.988
DCUN1D1	UBA3	ENSNLEP00000037729	ENSNLEP00000002646	DCN1-like protein.	Ubiquitin like modifier activating enzyme 3.	0.772
DCUN1D1	UBE2F	ENSNLEP00000037729	ENSNLEP00000013582	DCN1-like protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.883
DCUN1D1	UBE2M	ENSNLEP00000037729	ENSNLEP00000013633	DCN1-like protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.994
MOCS2	NAE1	ENSNLEP00000013400	ENSNLEP00000004923	Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.772

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