STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)    
Predicted Functional Partners:
CDK5R2
Cyclin-dependent kinase 5 activator.
    
 0.968
MAPT
Microtubule-associated protein.
    
 
 0.942
CCND2
Cyclin_C domain-containing protein.
    
 
 0.900
CABLES1
Cyclin N-terminal domain-containing protein.
    
 0.898
CDKN1B
Uncharacterized protein.
    
 
 0.873
C2CD5
C2 calcium dependent domain containing 5.
    
 
 0.819
CCND3
Uncharacterized protein; Belongs to the cyclin family.
    
 
 0.786
PPP1R1B
Protein phosphatase 1 regulatory inhibitor subunit 1B.
    
 0.778
PPARG
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
   
 
 0.778
CCNE1
Cyclin E1; Belongs to the cyclin family.
    
 
 0.747
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.