| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGR1 | EGR2 | ENSNLEP00000010928 | ENSNLEP00000044877 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Early growth response 2. | 0.981 |
| EGR1 | MET | ENSNLEP00000010928 | ENSNLEP00000024614 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.430 |
| EGR1 | RRAD | ENSNLEP00000010928 | ENSNLEP00000005037 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.650 |
| EGR2 | EGR1 | ENSNLEP00000044877 | ENSNLEP00000010928 | Early growth response 2. | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.981 |
| EGR2 | RRAD | ENSNLEP00000044877 | ENSNLEP00000005037 | Early growth response 2. | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.653 |
| ITSN1 | ITSN2 | ENSNLEP00000048437 | ENSNLEP00000001028 | Intersectin 1. | Intersectin 2. | 0.921 |
| ITSN1 | RRAD | ENSNLEP00000048437 | ENSNLEP00000005037 | Intersectin 1. | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.718 |
| ITSN2 | ITSN1 | ENSNLEP00000001028 | ENSNLEP00000048437 | Intersectin 2. | Intersectin 1. | 0.921 |
| ITSN2 | MET | ENSNLEP00000001028 | ENSNLEP00000024614 | Intersectin 2. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.683 |
| ITSN2 | MST1R | ENSNLEP00000001028 | ENSNLEP00000008444 | Intersectin 2. | Macrophage stimulating 1 receptor. | 0.683 |
| ITSN2 | RRAD | ENSNLEP00000001028 | ENSNLEP00000005037 | Intersectin 2. | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.848 |
| KALRN | RRAD | ENSNLEP00000000713 | ENSNLEP00000005037 | Uncharacterized protein. | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.525 |
| MET | EGR1 | ENSNLEP00000024614 | ENSNLEP00000010928 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.430 |
| MET | ITSN2 | ENSNLEP00000024614 | ENSNLEP00000001028 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Intersectin 2. | 0.683 |
| MET | MST1R | ENSNLEP00000024614 | ENSNLEP00000008444 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Macrophage stimulating 1 receptor. | 0.737 |
| MET | RRAD | ENSNLEP00000024614 | ENSNLEP00000005037 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.574 |
| MST1R | ITSN2 | ENSNLEP00000008444 | ENSNLEP00000001028 | Macrophage stimulating 1 receptor. | Intersectin 2. | 0.683 |
| MST1R | MET | ENSNLEP00000008444 | ENSNLEP00000024614 | Macrophage stimulating 1 receptor. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.737 |
| MST1R | RRAD | ENSNLEP00000008444 | ENSNLEP00000005037 | Macrophage stimulating 1 receptor. | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.574 |
| MYO9A | RRAD | ENSNLEP00000016794 | ENSNLEP00000005037 | Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.545 |
STRING v12.5 is now available!
