| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRCC3 | NLRP3 | ENSNLEP00000017599 | ENSNLEP00000005171 | BRCA1/BRCA2-containing complex subunit 3. | NLR family pyrin domain containing 3. | 0.969 |
| CASP1 | CASP8 | ENSNLEP00000044525 | ENSNLEP00000040588 | Caspase 1; Belongs to the peptidase C14A family. | Caspase 8; Belongs to the peptidase C14A family. | 0.973 |
| CASP1 | IL1B | ENSNLEP00000044525 | ENSNLEP00000044905 | Caspase 1; Belongs to the peptidase C14A family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.998 |
| CASP1 | NEK7 | ENSNLEP00000044525 | ENSNLEP00000021946 | Caspase 1; Belongs to the peptidase C14A family. | NIMA related kinase 7; Belongs to the protein kinase superfamily. | 0.539 |
| CASP1 | NLRP3 | ENSNLEP00000044525 | ENSNLEP00000005171 | Caspase 1; Belongs to the peptidase C14A family. | NLR family pyrin domain containing 3. | 0.962 |
| CASP1 | PYCARD | ENSNLEP00000044525 | ENSNLEP00000019741 | Caspase 1; Belongs to the peptidase C14A family. | PYD and CARD domain containing. | 0.998 |
| CASP1 | RIPK1 | ENSNLEP00000044525 | ENSNLEP00000013466 | Caspase 1; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 1. | 0.901 |
| CASP1 | RIPK3 | ENSNLEP00000044525 | ENSNLEP00000018788 | Caspase 1; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 3. | 0.909 |
| CASP1 | TXNIP | ENSNLEP00000044525 | ENSNLEP00000007046 | Caspase 1; Belongs to the peptidase C14A family. | Thioredoxin interacting protein. | 0.494 |
| CASP8 | CASP1 | ENSNLEP00000040588 | ENSNLEP00000044525 | Caspase 8; Belongs to the peptidase C14A family. | Caspase 1; Belongs to the peptidase C14A family. | 0.973 |
| CASP8 | IL1B | ENSNLEP00000040588 | ENSNLEP00000044905 | Caspase 8; Belongs to the peptidase C14A family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.740 |
| CASP8 | NLRP3 | ENSNLEP00000040588 | ENSNLEP00000005171 | Caspase 8; Belongs to the peptidase C14A family. | NLR family pyrin domain containing 3. | 0.940 |
| CASP8 | PYCARD | ENSNLEP00000040588 | ENSNLEP00000019741 | Caspase 8; Belongs to the peptidase C14A family. | PYD and CARD domain containing. | 0.992 |
| CASP8 | RIPK1 | ENSNLEP00000040588 | ENSNLEP00000013466 | Caspase 8; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 1. | 0.999 |
| CASP8 | RIPK3 | ENSNLEP00000040588 | ENSNLEP00000018788 | Caspase 8; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 3. | 0.998 |
| IL1B | CASP1 | ENSNLEP00000044905 | ENSNLEP00000044525 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Caspase 1; Belongs to the peptidase C14A family. | 0.998 |
| IL1B | CASP8 | ENSNLEP00000044905 | ENSNLEP00000040588 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Caspase 8; Belongs to the peptidase C14A family. | 0.740 |
| IL1B | NLRP3 | ENSNLEP00000044905 | ENSNLEP00000005171 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | NLR family pyrin domain containing 3. | 0.965 |
| IL1B | PYCARD | ENSNLEP00000044905 | ENSNLEP00000019741 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | PYD and CARD domain containing. | 0.979 |
| IL1B | RIPK1 | ENSNLEP00000044905 | ENSNLEP00000013466 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Receptor interacting serine/threonine kinase 1. | 0.424 |
