IL12B protein (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IL12B

Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)

Predicted Functional Partners:

IL12A

0.996

IL23A

0.996

IL23R

0.983

IL12RB1

0.967

IL12RB2

0.951

IFNGR1

0.818

IFNGR2

0.802

IL2RA

0.801

IL6ST

0.796

IL27RA

0.796

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFNGR1	IFNGR2	ENSNLEP00000038184	ENSNLEP00000004692	Interferon gamma receptor 1.	Interferon gamma receptor 2.	0.999
IFNGR1	IL12B	ENSNLEP00000038184	ENSNLEP00000005210	Interferon gamma receptor 1.	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.818
IFNGR1	IL12RB1	ENSNLEP00000038184	ENSNLEP00000007167	Interferon gamma receptor 1.	Uncharacterized protein.	0.748
IFNGR1	IL23A	ENSNLEP00000038184	ENSNLEP00000021241	Interferon gamma receptor 1.	Interleukin 23 subunit alpha.	0.670
IFNGR1	IL27RA	ENSNLEP00000038184	ENSNLEP00000016201	Interferon gamma receptor 1.	Interleukin 27 receptor subunit alpha.	0.485
IFNGR1	IL2RA	ENSNLEP00000038184	ENSNLEP00000014170	Interferon gamma receptor 1.	Interleukin 2 receptor subunit alpha.	0.577
IFNGR2	IFNGR1	ENSNLEP00000004692	ENSNLEP00000038184	Interferon gamma receptor 2.	Interferon gamma receptor 1.	0.999
IFNGR2	IL12B	ENSNLEP00000004692	ENSNLEP00000005210	Interferon gamma receptor 2.	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.802
IFNGR2	IL12RB1	ENSNLEP00000004692	ENSNLEP00000007167	Interferon gamma receptor 2.	Uncharacterized protein.	0.708
IFNGR2	IL23A	ENSNLEP00000004692	ENSNLEP00000021241	Interferon gamma receptor 2.	Interleukin 23 subunit alpha.	0.740
IL12A	IL12B	ENSNLEP00000005293	ENSNLEP00000005210	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.996
IL12A	IL12RB1	ENSNLEP00000005293	ENSNLEP00000007167	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Uncharacterized protein.	0.706
IL12A	IL12RB2	ENSNLEP00000005293	ENSNLEP00000011248	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin 12 receptor subunit beta 2.	0.525
IL12A	IL23A	ENSNLEP00000005293	ENSNLEP00000021241	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin 23 subunit alpha.	0.502
IL12A	IL27RA	ENSNLEP00000005293	ENSNLEP00000016201	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin 27 receptor subunit alpha.	0.483
IL12B	IFNGR1	ENSNLEP00000005210	ENSNLEP00000038184	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interferon gamma receptor 1.	0.818
IL12B	IFNGR2	ENSNLEP00000005210	ENSNLEP00000004692	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interferon gamma receptor 2.	0.802
IL12B	IL12A	ENSNLEP00000005210	ENSNLEP00000005293	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.996
IL12B	IL12RB1	ENSNLEP00000005210	ENSNLEP00000007167	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Uncharacterized protein.	0.967
IL12B	IL12RB2	ENSNLEP00000005210	ENSNLEP00000011248	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin 12 receptor subunit beta 2.	0.951

page 1 of 4

Server load: low (22%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About