| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMD1 | DNMT1 | ENSNLEP00000015588 | ENSNLEP00000027390 | S-adenosylmethionine decarboxylase proenzyme. | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.902 |
| AMD1 | DNMT3A | ENSNLEP00000015588 | ENSNLEP00000024130 | S-adenosylmethionine decarboxylase proenzyme. | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.900 |
| AMD1 | GNMT | ENSNLEP00000015588 | ENSNLEP00000048464 | S-adenosylmethionine decarboxylase proenzyme. | Glycine N-methyltransferase. | 0.928 |
| AMD1 | MAT1A | ENSNLEP00000015588 | ENSNLEP00000013009 | S-adenosylmethionine decarboxylase proenzyme. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.931 |
| AMD1 | MAT2A | ENSNLEP00000015588 | ENSNLEP00000044620 | S-adenosylmethionine decarboxylase proenzyme. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.931 |
| AMD1 | MAT2B | ENSNLEP00000015588 | ENSNLEP00000005823 | S-adenosylmethionine decarboxylase proenzyme. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.913 |
| AMD1 | MTR | ENSNLEP00000015588 | ENSNLEP00000004339 | S-adenosylmethionine decarboxylase proenzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.527 |
| BHMT | BHMT2 | ENSNLEP00000015595 | ENSNLEP00000040447 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | 0.997 |
| BHMT | ENSNLEP00000024955 | ENSNLEP00000015595 | ENSNLEP00000024955 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.600 |
| BHMT | GNMT | ENSNLEP00000015595 | ENSNLEP00000048464 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Glycine N-methyltransferase. | 0.547 |
| BHMT | MAT1A | ENSNLEP00000015595 | ENSNLEP00000013009 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.971 |
| BHMT | MAT2A | ENSNLEP00000015595 | ENSNLEP00000044620 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.957 |
| BHMT | MAT2B | ENSNLEP00000015595 | ENSNLEP00000005823 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.936 |
| BHMT | MTR | ENSNLEP00000015595 | ENSNLEP00000004339 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.946 |
| BHMT2 | BHMT | ENSNLEP00000040447 | ENSNLEP00000015595 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | 0.997 |
| BHMT2 | ENSNLEP00000024955 | ENSNLEP00000040447 | ENSNLEP00000024955 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.600 |
| BHMT2 | GNMT | ENSNLEP00000040447 | ENSNLEP00000048464 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | Glycine N-methyltransferase. | 0.497 |
| BHMT2 | MAT1A | ENSNLEP00000040447 | ENSNLEP00000013009 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.961 |
| BHMT2 | MAT2A | ENSNLEP00000040447 | ENSNLEP00000044620 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.957 |
| BHMT2 | MAT2B | ENSNLEP00000040447 | ENSNLEP00000005823 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.936 |
