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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)    
Predicted Functional Partners:
CYP51A1
Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.
   
 
 0.923
SQLE
Squalene epoxidase.
   
 
 0.922
ERG28
Ergosterol biosynthesis 28 homolog.
   
 
 0.915
SC5D
Sterol-C5-desaturase; Belongs to the sterol desaturase family.
   
 0.875
FAXDC2
Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family.
   
 0.839
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
   
 0.839
MSMO1
Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.
   
 0.839
TM7SF2
Transmembrane 7 superfamily member 2.
   
 
 0.812
DHCR7
7-dehydrocholesterol reductase.
   
 
 0.812
LBR
Lamin B receptor.
   
 
 0.812
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.