| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIM2 | TP53BP1 | ENSNLEP00000015970 | ENSNLEP00000006165 | Absent in melanoma 2. | Tumor protein p53 binding protein 1. | 0.948 |
| ATM | BRCA1 | ENSNLEP00000008823 | ENSNLEP00000042201 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRCA1 DNA repair associated. | 0.999 |
| ATM | CHEK2 | ENSNLEP00000008823 | ENSNLEP00000002824 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Checkpoint kinase 2. | 0.996 |
| ATM | H2AX | ENSNLEP00000008823 | ENSNLEP00000038777 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Histone H2A; Belongs to the histone H2A family. | 0.980 |
| ATM | MDC1 | ENSNLEP00000008823 | ENSNLEP00000006466 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Mediator of DNA damage checkpoint 1. | 0.991 |
| ATM | PAXIP1 | ENSNLEP00000008823 | ENSNLEP00000012860 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | PAX interacting protein 1. | 0.938 |
| ATM | RNF168 | ENSNLEP00000008823 | ENSNLEP00000001828 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.827 |
| ATM | TOPBP1 | ENSNLEP00000008823 | ENSNLEP00000004327 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | DNA topoisomerase II binding protein 1. | 0.853 |
| ATM | TP53BP1 | ENSNLEP00000008823 | ENSNLEP00000006165 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Tumor protein p53 binding protein 1. | 0.992 |
| BRCA1 | ATM | ENSNLEP00000042201 | ENSNLEP00000008823 | BRCA1 DNA repair associated. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.999 |
| BRCA1 | CHEK2 | ENSNLEP00000042201 | ENSNLEP00000002824 | BRCA1 DNA repair associated. | Checkpoint kinase 2. | 0.992 |
| BRCA1 | H2AX | ENSNLEP00000042201 | ENSNLEP00000038777 | BRCA1 DNA repair associated. | Histone H2A; Belongs to the histone H2A family. | 0.986 |
| BRCA1 | MDC1 | ENSNLEP00000042201 | ENSNLEP00000006466 | BRCA1 DNA repair associated. | Mediator of DNA damage checkpoint 1. | 0.989 |
| BRCA1 | PAXIP1 | ENSNLEP00000042201 | ENSNLEP00000012860 | BRCA1 DNA repair associated. | PAX interacting protein 1. | 0.793 |
| BRCA1 | RNF168 | ENSNLEP00000042201 | ENSNLEP00000001828 | BRCA1 DNA repair associated. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.901 |
| BRCA1 | TOPBP1 | ENSNLEP00000042201 | ENSNLEP00000004327 | BRCA1 DNA repair associated. | DNA topoisomerase II binding protein 1. | 0.998 |
| BRCA1 | TP53BP1 | ENSNLEP00000042201 | ENSNLEP00000006165 | BRCA1 DNA repair associated. | Tumor protein p53 binding protein 1. | 0.996 |
| CHEK2 | ATM | ENSNLEP00000002824 | ENSNLEP00000008823 | Checkpoint kinase 2. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.996 |
| CHEK2 | BRCA1 | ENSNLEP00000002824 | ENSNLEP00000042201 | Checkpoint kinase 2. | BRCA1 DNA repair associated. | 0.992 |
| CHEK2 | H2AX | ENSNLEP00000002824 | ENSNLEP00000038777 | Checkpoint kinase 2. | Histone H2A; Belongs to the histone H2A family. | 0.793 |
STRING v12.5 is now available!
