UBE2N protein (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSNLEP00000034619	ENSNLEP00000049227	ENSNLEP00000034619	ENSNLEP00000049227	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.702
ENSNLEP00000034619	HLTF	ENSNLEP00000034619	ENSNLEP00000003324	Ubiquitin-like domain-containing protein.	Helicase like transcription factor.	0.655
ENSNLEP00000034619	OTUB1	ENSNLEP00000034619	ENSNLEP00000034336	Ubiquitin-like domain-containing protein.	Ubiquitin thioesterase.	0.798
ENSNLEP00000034619	PRKN	ENSNLEP00000034619	ENSNLEP00000013941	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.909
ENSNLEP00000034619	RNF168	ENSNLEP00000034619	ENSNLEP00000001828	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.895
ENSNLEP00000034619	RNF8	ENSNLEP00000034619	ENSNLEP00000013584	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.865
ENSNLEP00000034619	TRAF6	ENSNLEP00000034619	ENSNLEP00000021805	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.894
ENSNLEP00000034619	UBA1	ENSNLEP00000034619	ENSNLEP00000003842	Ubiquitin-like domain-containing protein.	Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.909
ENSNLEP00000034619	UBE2N	ENSNLEP00000034619	ENSNLEP00000006897	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.879
ENSNLEP00000034619	UBE2V2	ENSNLEP00000034619	ENSNLEP00000035256	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 V2.	0.944
ENSNLEP00000049227	ENSNLEP00000034619	ENSNLEP00000049227	ENSNLEP00000034619	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.702
ENSNLEP00000049227	HLTF	ENSNLEP00000049227	ENSNLEP00000003324	Uncharacterized protein.	Helicase like transcription factor.	0.474
ENSNLEP00000049227	PRKN	ENSNLEP00000049227	ENSNLEP00000013941	Uncharacterized protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.755
ENSNLEP00000049227	RNF8	ENSNLEP00000049227	ENSNLEP00000013584	Uncharacterized protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.718
ENSNLEP00000049227	TRAF6	ENSNLEP00000049227	ENSNLEP00000021805	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.483
ENSNLEP00000049227	UBA1	ENSNLEP00000049227	ENSNLEP00000003842	Uncharacterized protein.	Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.718
ENSNLEP00000049227	UBE2N	ENSNLEP00000049227	ENSNLEP00000006897	Uncharacterized protein.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.862
ENSNLEP00000049227	UBE2V2	ENSNLEP00000049227	ENSNLEP00000035256	Uncharacterized protein.	Ubiquitin conjugating enzyme E2 V2.	0.536
HLTF	ENSNLEP00000034619	ENSNLEP00000003324	ENSNLEP00000034619	Helicase like transcription factor.	Ubiquitin-like domain-containing protein.	0.655
HLTF	ENSNLEP00000049227	ENSNLEP00000003324	ENSNLEP00000049227	Helicase like transcription factor.	Uncharacterized protein.	0.474

page 1 of 4

Server load: low (14%) [HD]

Share

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About