TOP1 protein (Nomascus leucogenys) - STRING interaction network

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TOP1

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)

Predicted Functional Partners:

TDP1

0.916

TOP2A

0.905

TOP2B

0.875

SRSF1

0.850

TOPORS

0.801

PARP1

0.782

WRN

0.709

ALYREF

0.705

XRCC5

0.699

PRKDC

0.684

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALYREF	SRSF1	ENSNLEP00000041346	ENSNLEP00000009873	Aly/REF export factor.	Uncharacterized protein.	0.933
ALYREF	TOP1	ENSNLEP00000041346	ENSNLEP00000007880	Aly/REF export factor.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.705
PARP1	PRKDC	ENSNLEP00000016881	ENSNLEP00000016119	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	Protein kinase, DNA-activated, catalytic subunit.	0.922
PARP1	TDP1	ENSNLEP00000016881	ENSNLEP00000040013	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	Tyrosyl-DNA phosphodiesterase 1.	0.689
PARP1	TOP1	ENSNLEP00000016881	ENSNLEP00000007880	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.782
PARP1	TOP2A	ENSNLEP00000016881	ENSNLEP00000002285	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.416
PARP1	TOP2B	ENSNLEP00000016881	ENSNLEP00000037661	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.418
PARP1	WRN	ENSNLEP00000016881	ENSNLEP00000045895	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	WRN RecQ like helicase.	0.728
PARP1	XRCC5	ENSNLEP00000016881	ENSNLEP00000008862	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.970
PRKDC	PARP1	ENSNLEP00000016119	ENSNLEP00000016881	Protein kinase, DNA-activated, catalytic subunit.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.922
PRKDC	TDP1	ENSNLEP00000016119	ENSNLEP00000040013	Protein kinase, DNA-activated, catalytic subunit.	Tyrosyl-DNA phosphodiesterase 1.	0.647
PRKDC	TOP1	ENSNLEP00000016119	ENSNLEP00000007880	Protein kinase, DNA-activated, catalytic subunit.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.684
PRKDC	TOP2A	ENSNLEP00000016119	ENSNLEP00000002285	Protein kinase, DNA-activated, catalytic subunit.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.558
PRKDC	WRN	ENSNLEP00000016119	ENSNLEP00000045895	Protein kinase, DNA-activated, catalytic subunit.	WRN RecQ like helicase.	0.776
PRKDC	XRCC5	ENSNLEP00000016119	ENSNLEP00000008862	Protein kinase, DNA-activated, catalytic subunit.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.998
SRSF1	ALYREF	ENSNLEP00000009873	ENSNLEP00000041346	Uncharacterized protein.	Aly/REF export factor.	0.933
SRSF1	TOP1	ENSNLEP00000009873	ENSNLEP00000007880	Uncharacterized protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.850
TDP1	PARP1	ENSNLEP00000040013	ENSNLEP00000016881	Tyrosyl-DNA phosphodiesterase 1.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.689
TDP1	PRKDC	ENSNLEP00000040013	ENSNLEP00000016119	Tyrosyl-DNA phosphodiesterase 1.	Protein kinase, DNA-activated, catalytic subunit.	0.647
TDP1	TOP1	ENSNLEP00000040013	ENSNLEP00000007880	Tyrosyl-DNA phosphodiesterase 1.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.916

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