node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATM | ATR | ENSNLEP00000008823 | ENSNLEP00000025629 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.968 |
ATM | ATRIP | ENSNLEP00000008823 | ENSNLEP00000007884 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | ATR interacting protein. | 0.944 |
ATM | BRCA1 | ENSNLEP00000008823 | ENSNLEP00000042201 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRCA1 DNA repair associated. | 0.999 |
ATM | FANCG | ENSNLEP00000008823 | ENSNLEP00000005687 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | FA complementation group G. | 0.607 |
ATM | FANCI | ENSNLEP00000008823 | ENSNLEP00000014138 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | FA complementation group I. | 0.801 |
ATM | FANCM | ENSNLEP00000008823 | ENSNLEP00000048241 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | FA complementation group M. | 0.623 |
ATM | RAD9A | ENSNLEP00000008823 | ENSNLEP00000007725 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cell cycle checkpoint control protein; Belongs to the rad9 family. | 0.888 |
ATM | RPA1 | ENSNLEP00000008823 | ENSNLEP00000020837 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.844 |
ATM | TOPBP1 | ENSNLEP00000008823 | ENSNLEP00000004327 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | DNA topoisomerase II binding protein 1. | 0.853 |
ATM | WRN | ENSNLEP00000008823 | ENSNLEP00000045895 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | WRN RecQ like helicase. | 0.978 |
ATR | ATM | ENSNLEP00000025629 | ENSNLEP00000008823 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.968 |
ATR | ATRIP | ENSNLEP00000025629 | ENSNLEP00000007884 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | ATR interacting protein. | 0.999 |
ATR | BRCA1 | ENSNLEP00000025629 | ENSNLEP00000042201 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | BRCA1 DNA repair associated. | 0.996 |
ATR | FANCG | ENSNLEP00000025629 | ENSNLEP00000005687 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | FA complementation group G. | 0.956 |
ATR | FANCI | ENSNLEP00000025629 | ENSNLEP00000014138 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | FA complementation group I. | 0.969 |
ATR | FANCM | ENSNLEP00000025629 | ENSNLEP00000048241 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | FA complementation group M. | 0.992 |
ATR | RAD9A | ENSNLEP00000025629 | ENSNLEP00000007725 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Cell cycle checkpoint control protein; Belongs to the rad9 family. | 0.986 |
ATR | RPA1 | ENSNLEP00000025629 | ENSNLEP00000020837 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.937 |
ATR | TOPBP1 | ENSNLEP00000025629 | ENSNLEP00000004327 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | DNA topoisomerase II binding protein 1. | 0.963 |
ATR | WRN | ENSNLEP00000025629 | ENSNLEP00000045895 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | WRN RecQ like helicase. | 0.987 |