| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AOX1 | LOC100583419 | ENSNLEP00000031058 | ENSNLEP00000036097 | Aldehyde oxidase 1. | FAD-binding PCMH-type domain-containing protein. | 0.902 |
| AOX1 | NNMT | ENSNLEP00000031058 | ENSNLEP00000008931 | Aldehyde oxidase 1. | Nicotinamide N-methyltransferase. | 0.909 |
| AOX1 | PNP | ENSNLEP00000031058 | ENSNLEP00000013361 | Aldehyde oxidase 1. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.599 |
| LOC100583419 | AOX1 | ENSNLEP00000036097 | ENSNLEP00000031058 | FAD-binding PCMH-type domain-containing protein. | Aldehyde oxidase 1. | 0.902 |
| LOC100583419 | NNMT | ENSNLEP00000036097 | ENSNLEP00000008931 | FAD-binding PCMH-type domain-containing protein. | Nicotinamide N-methyltransferase. | 0.909 |
| LOC100583419 | PNP | ENSNLEP00000036097 | ENSNLEP00000013361 | FAD-binding PCMH-type domain-containing protein. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.599 |
| NAMPT | NNMT | ENSNLEP00000010796 | ENSNLEP00000008931 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Nicotinamide N-methyltransferase. | 0.907 |
| NAMPT | PNP | ENSNLEP00000010796 | ENSNLEP00000013361 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.916 |
| NAMPT | SARM1 | ENSNLEP00000010796 | ENSNLEP00000002578 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sterile alpha and TIR motif containing 1. | 0.934 |
| NAMPT | SIRT1 | ENSNLEP00000010796 | ENSNLEP00000014593 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sirtuin 1. | 0.960 |
| NAMPT | SIRT2 | ENSNLEP00000010796 | ENSNLEP00000017842 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.935 |
| NAMPT | SIRT4 | ENSNLEP00000010796 | ENSNLEP00000018942 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.935 |
| NAMPT | SIRT5 | ENSNLEP00000010796 | ENSNLEP00000026965 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] | 0.927 |
| NAMPT | SIRT7 | ENSNLEP00000010796 | ENSNLEP00000009137 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sirtuin 7. | 0.921 |
| NNMT | AOX1 | ENSNLEP00000008931 | ENSNLEP00000031058 | Nicotinamide N-methyltransferase. | Aldehyde oxidase 1. | 0.909 |
| NNMT | LOC100583419 | ENSNLEP00000008931 | ENSNLEP00000036097 | Nicotinamide N-methyltransferase. | FAD-binding PCMH-type domain-containing protein. | 0.909 |
| NNMT | NAMPT | ENSNLEP00000008931 | ENSNLEP00000010796 | Nicotinamide N-methyltransferase. | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.907 |
| NNMT | PNP | ENSNLEP00000008931 | ENSNLEP00000013361 | Nicotinamide N-methyltransferase. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.900 |
| NNMT | SARM1 | ENSNLEP00000008931 | ENSNLEP00000002578 | Nicotinamide N-methyltransferase. | Sterile alpha and TIR motif containing 1. | 0.900 |
| NNMT | SIRT1 | ENSNLEP00000008931 | ENSNLEP00000014593 | Nicotinamide N-methyltransferase. | Sirtuin 1. | 0.902 |
