STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)    
Predicted Functional Partners:
APP
Amyloid beta precursor protein.
    
 0.996
RTN3
Reticulon.
   
 0.971
GGA1
Golgi associated, gamma adaptin ear containing, ARF binding protein 1.
    
 0.943
BACE2
Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.
  
  
 
0.901
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 
 0.781
GGA3
Golgi associated, gamma adaptin ear containing, ARF binding protein 3.
    
 0.764
FURIN
Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.
   
 0.744
APLP1
Amyloid beta precursor like protein 1.
    
 0.740
APLP2
Amyloid beta precursor like protein 2.
    
 0.732
ADAM10
ADAM metallopeptidase domain 10.
    
 
 0.706
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.