PDZD3 protein (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PDZD3

PDZ domain containing 3. (549 aa)

Predicted Functional Partners:

GUCY2C

0.725

CFTR

0.713

SLC34A1

0.628

NPR3

0.569

IFT80

0.551

IFT57

0.542

IFT88

0.539

IFT172

0.536

TRAF3IP1

0.534

CASK

0.512

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASK	PDZD3	ENSNLEP00000002678	ENSNLEP00000009015	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	PDZ domain containing 3.	0.512
CFTR	GUCY2C	ENSNLEP00000014239	ENSNLEP00000004736	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Guanylate cyclase.	0.633
CFTR	IFT88	ENSNLEP00000014239	ENSNLEP00000002109	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Intraflagellar transport 88.	0.483
CFTR	PDZD3	ENSNLEP00000014239	ENSNLEP00000009015	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	PDZ domain containing 3.	0.713
GUCY2C	CFTR	ENSNLEP00000004736	ENSNLEP00000014239	Guanylate cyclase.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	0.633
GUCY2C	NPR3	ENSNLEP00000004736	ENSNLEP00000017220	Guanylate cyclase.	Natriuretic peptide receptor 3.	0.619
GUCY2C	PDZD3	ENSNLEP00000004736	ENSNLEP00000009015	Guanylate cyclase.	PDZ domain containing 3.	0.725
IFT172	IFT57	ENSNLEP00000004557	ENSNLEP00000027391	Intraflagellar transport 172.	Intraflagellar transport 57.	0.997
IFT172	IFT80	ENSNLEP00000004557	ENSNLEP00000029676	Intraflagellar transport 172.	Intraflagellar transport 80.	0.996
IFT172	IFT88	ENSNLEP00000004557	ENSNLEP00000002109	Intraflagellar transport 172.	Intraflagellar transport 88.	0.994
IFT172	PDZD3	ENSNLEP00000004557	ENSNLEP00000009015	Intraflagellar transport 172.	PDZ domain containing 3.	0.536
IFT172	TRAF3IP1	ENSNLEP00000004557	ENSNLEP00000013770	Intraflagellar transport 172.	TRAF3 interacting protein 1.	0.994
IFT57	IFT172	ENSNLEP00000027391	ENSNLEP00000004557	Intraflagellar transport 57.	Intraflagellar transport 172.	0.997
IFT57	IFT80	ENSNLEP00000027391	ENSNLEP00000029676	Intraflagellar transport 57.	Intraflagellar transport 80.	0.997
IFT57	IFT88	ENSNLEP00000027391	ENSNLEP00000002109	Intraflagellar transport 57.	Intraflagellar transport 88.	0.996
IFT57	PDZD3	ENSNLEP00000027391	ENSNLEP00000009015	Intraflagellar transport 57.	PDZ domain containing 3.	0.542
IFT57	TRAF3IP1	ENSNLEP00000027391	ENSNLEP00000013770	Intraflagellar transport 57.	TRAF3 interacting protein 1.	0.997
IFT80	IFT172	ENSNLEP00000029676	ENSNLEP00000004557	Intraflagellar transport 80.	Intraflagellar transport 172.	0.996
IFT80	IFT57	ENSNLEP00000029676	ENSNLEP00000027391	Intraflagellar transport 80.	Intraflagellar transport 57.	0.997
IFT80	IFT88	ENSNLEP00000029676	ENSNLEP00000002109	Intraflagellar transport 80.	Intraflagellar transport 88.	0.995

page 1 of 3

Server load: low (28%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2025

Credits

Access

Info

About