| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APLF | LIG4 | ENSNLEP00000012214 | ENSNLEP00000009615 | Aprataxin and PNKP like factor. | DNA ligase. | 0.957 |
| APLF | LOC100580673 | ENSNLEP00000012214 | ENSNLEP00000043734 | Aprataxin and PNKP like factor. | Ku domain-containing protein. | 0.837 |
| APLF | NHEJ1 | ENSNLEP00000012214 | ENSNLEP00000011039 | Aprataxin and PNKP like factor. | Non-homologous end joining factor 1. | 0.472 |
| APLF | PAXX | ENSNLEP00000012214 | ENSNLEP00000010678 | Aprataxin and PNKP like factor. | Uncharacterized protein. | 0.574 |
| APLF | PRKDC | ENSNLEP00000012214 | ENSNLEP00000016119 | Aprataxin and PNKP like factor. | Protein kinase, DNA-activated, catalytic subunit. | 0.528 |
| APLF | XRCC4 | ENSNLEP00000012214 | ENSNLEP00000025879 | Aprataxin and PNKP like factor. | Uncharacterized protein. | 0.407 |
| APLF | XRCC5 | ENSNLEP00000012214 | ENSNLEP00000008862 | Aprataxin and PNKP like factor. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.948 |
| APLF | XRCC6 | ENSNLEP00000012214 | ENSNLEP00000018935 | Aprataxin and PNKP like factor. | X-ray repair cross complementing 6. | 0.837 |
| ATM | DCLRE1C | ENSNLEP00000008823 | ENSNLEP00000028695 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Uncharacterized protein. | 0.860 |
| ATM | LIG4 | ENSNLEP00000008823 | ENSNLEP00000009615 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | DNA ligase. | 0.892 |
| ATM | LOC100580673 | ENSNLEP00000008823 | ENSNLEP00000043734 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Ku domain-containing protein. | 0.802 |
| ATM | NHEJ1 | ENSNLEP00000008823 | ENSNLEP00000011039 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Non-homologous end joining factor 1. | 0.753 |
| ATM | PAXX | ENSNLEP00000008823 | ENSNLEP00000010678 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Uncharacterized protein. | 0.499 |
| ATM | PRKDC | ENSNLEP00000008823 | ENSNLEP00000016119 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Protein kinase, DNA-activated, catalytic subunit. | 0.935 |
| ATM | XRCC4 | ENSNLEP00000008823 | ENSNLEP00000025879 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Uncharacterized protein. | 0.405 |
| ATM | XRCC5 | ENSNLEP00000008823 | ENSNLEP00000008862 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.976 |
| ATM | XRCC6 | ENSNLEP00000008823 | ENSNLEP00000018935 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | X-ray repair cross complementing 6. | 0.867 |
| DCLRE1C | ATM | ENSNLEP00000028695 | ENSNLEP00000008823 | Uncharacterized protein. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.860 |
| DCLRE1C | LIG4 | ENSNLEP00000028695 | ENSNLEP00000009615 | Uncharacterized protein. | DNA ligase. | 0.975 |
| DCLRE1C | LOC100580673 | ENSNLEP00000028695 | ENSNLEP00000043734 | Uncharacterized protein. | Ku domain-containing protein. | 0.846 |
