G1R9J5_NOMLE protein (Nomascus leucogenys) - STRING interaction network

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Score

G1R9J5_NOMLE

SAM domain-containing protein. (574 aa)

Predicted Functional Partners:

TP63

0.985

YAP1

0.945

ENSNLEP00000032543

0.945

TP53BP2

0.938

EP300

0.931

BCL2L1

0.901

MDM4

0.901

ITCH

0.879

ABL1

0.860

ATM

0.829

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ATM	ENSNLEP00000015256	ENSNLEP00000008823	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.974
ABL1	BCL2L1	ENSNLEP00000015256	ENSNLEP00000011718	Tyrosine-protein kinase.	BCL2 like 1.	0.506
ABL1	ENSNLEP00000032543	ENSNLEP00000015256	ENSNLEP00000032543	Tyrosine-protein kinase.	Uncharacterized protein.	0.661
ABL1	EP300	ENSNLEP00000015256	ENSNLEP00000035934	Tyrosine-protein kinase.	E1A binding protein p300.	0.531
ABL1	G1R9J5_NOMLE	ENSNLEP00000015256	ENSNLEP00000009887	Tyrosine-protein kinase.	SAM domain-containing protein.	0.860
ABL1	YAP1	ENSNLEP00000015256	ENSNLEP00000031727	Tyrosine-protein kinase.	Uncharacterized protein.	0.661
ATM	ABL1	ENSNLEP00000008823	ENSNLEP00000015256	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.974
ATM	BCL2L1	ENSNLEP00000008823	ENSNLEP00000011718	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 like 1.	0.455
ATM	EP300	ENSNLEP00000008823	ENSNLEP00000035934	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E1A binding protein p300.	0.694
ATM	G1R9J5_NOMLE	ENSNLEP00000008823	ENSNLEP00000009887	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SAM domain-containing protein.	0.829
ATM	MDM4	ENSNLEP00000008823	ENSNLEP00000023664	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.872
ATM	TP63	ENSNLEP00000008823	ENSNLEP00000032932	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.829
BCL2L1	ABL1	ENSNLEP00000011718	ENSNLEP00000015256	BCL2 like 1.	Tyrosine-protein kinase.	0.506
BCL2L1	ATM	ENSNLEP00000011718	ENSNLEP00000008823	BCL2 like 1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.455
BCL2L1	G1R9J5_NOMLE	ENSNLEP00000011718	ENSNLEP00000009887	BCL2 like 1.	SAM domain-containing protein.	0.901
BCL2L1	TP53BP2	ENSNLEP00000011718	ENSNLEP00000025593	BCL2 like 1.	Tumor protein p53 binding protein 2.	0.485
BCL2L1	TP63	ENSNLEP00000011718	ENSNLEP00000032932	BCL2 like 1.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.529
ENSNLEP00000032543	ABL1	ENSNLEP00000032543	ENSNLEP00000015256	Uncharacterized protein.	Tyrosine-protein kinase.	0.661
ENSNLEP00000032543	EP300	ENSNLEP00000032543	ENSNLEP00000035934	Uncharacterized protein.	E1A binding protein p300.	0.418
ENSNLEP00000032543	G1R9J5_NOMLE	ENSNLEP00000032543	ENSNLEP00000009887	Uncharacterized protein.	SAM domain-containing protein.	0.945

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