NLRP6 protein (Nomascus leucogenys) - STRING interaction network

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NLRP6

Pyrin domain-containing protein. (633 aa)

Predicted Functional Partners:

PKP3

0.699

AK9

0.662

NLRC4

0.647

PYCARD

0.642

CASP1

0.624

MEFV

0.612

PGGHG

0.575

NOD2

0.574

IL18

0.565

AIM2

0.536

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	CASP1	ENSNLEP00000015970	ENSNLEP00000044525	Absent in melanoma 2.	Caspase 1; Belongs to the peptidase C14A family.	0.993
AIM2	IL18	ENSNLEP00000015970	ENSNLEP00000038207	Absent in melanoma 2.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.698
AIM2	MEFV	ENSNLEP00000015970	ENSNLEP00000011730	Absent in melanoma 2.	MEFV innate immuity regulator, pyrin.	0.757
AIM2	NLRC4	ENSNLEP00000015970	ENSNLEP00000019081	Absent in melanoma 2.	NLR family CARD domain containing 4.	0.801
AIM2	NLRP6	ENSNLEP00000015970	ENSNLEP00000009988	Absent in melanoma 2.	Pyrin domain-containing protein.	0.536
AIM2	PYCARD	ENSNLEP00000015970	ENSNLEP00000019741	Absent in melanoma 2.	PYD and CARD domain containing.	0.997
AK9	NLRP6	ENSNLEP00000015410	ENSNLEP00000009988	Adenylate kinase 9.	Pyrin domain-containing protein.	0.662
AK9	NOD2	ENSNLEP00000015410	ENSNLEP00000001073	Adenylate kinase 9.	Nucleotide binding oligomerization domain containing 2.	0.662
CASP1	AIM2	ENSNLEP00000044525	ENSNLEP00000015970	Caspase 1; Belongs to the peptidase C14A family.	Absent in melanoma 2.	0.993
CASP1	IL18	ENSNLEP00000044525	ENSNLEP00000038207	Caspase 1; Belongs to the peptidase C14A family.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.993
CASP1	MEFV	ENSNLEP00000044525	ENSNLEP00000011730	Caspase 1; Belongs to the peptidase C14A family.	MEFV innate immuity regulator, pyrin.	0.989
CASP1	NLRC4	ENSNLEP00000044525	ENSNLEP00000019081	Caspase 1; Belongs to the peptidase C14A family.	NLR family CARD domain containing 4.	0.979
CASP1	NLRP6	ENSNLEP00000044525	ENSNLEP00000009988	Caspase 1; Belongs to the peptidase C14A family.	Pyrin domain-containing protein.	0.624
CASP1	NOD2	ENSNLEP00000044525	ENSNLEP00000001073	Caspase 1; Belongs to the peptidase C14A family.	Nucleotide binding oligomerization domain containing 2.	0.847
CASP1	PYCARD	ENSNLEP00000044525	ENSNLEP00000019741	Caspase 1; Belongs to the peptidase C14A family.	PYD and CARD domain containing.	0.998
IL18	AIM2	ENSNLEP00000038207	ENSNLEP00000015970	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Absent in melanoma 2.	0.698
IL18	CASP1	ENSNLEP00000038207	ENSNLEP00000044525	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Caspase 1; Belongs to the peptidase C14A family.	0.993
IL18	MEFV	ENSNLEP00000038207	ENSNLEP00000011730	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	MEFV innate immuity regulator, pyrin.	0.482
IL18	NLRC4	ENSNLEP00000038207	ENSNLEP00000019081	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	NLR family CARD domain containing 4.	0.711
IL18	NLRP6	ENSNLEP00000038207	ENSNLEP00000009988	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Pyrin domain-containing protein.	0.565

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