Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NEDD4LUncharacterized protein. (1236 aa)    
Predicted Functional Partners:
SGK1
Non-specific serine/threonine protein kinase.
   
 0.997
SCNN1G
Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
    
 0.993
SCNN1A
Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
    
 0.973
SMAD7
Mothers against decapentaplegic homolog.
    
 0.970
NEDD4
NEDD4 E3 ubiquitin protein ligase.
  
 
0.961
SFN
Stratifin; Belongs to the 14-3-3 family.
    
 0.937
DLG3
Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.
    
 0.928
SCNN1B
Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
    
 0.926
EGFR
Receptor protein-tyrosine kinase.
    
 0.903
SMAD3
Mothers against decapentaplegic homolog.
    
 0.897
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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