node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSF1 | GRB2 | ENSNLEP00000004199 | ENSNLEP00000040743 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Growth factor receptor bound protein 2. | 0.596 |
CSF1 | KIT | ENSNLEP00000004199 | ENSNLEP00000010174 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.974 |
CSF1 | KITLG | ENSNLEP00000004199 | ENSNLEP00000006667 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | 0.502 |
CSF1 | KRAS | ENSNLEP00000004199 | ENSNLEP00000006371 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | KRAS proto-oncogene, GTPase. | 0.408 |
CSF1 | STAT3 | ENSNLEP00000004199 | ENSNLEP00000014018 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Signal transducer and activator of transcription. | 0.606 |
GRB2 | CSF1 | ENSNLEP00000040743 | ENSNLEP00000004199 | Growth factor receptor bound protein 2. | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | 0.596 |
GRB2 | KIT | ENSNLEP00000040743 | ENSNLEP00000010174 | Growth factor receptor bound protein 2. | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.997 |
GRB2 | KITLG | ENSNLEP00000040743 | ENSNLEP00000006667 | Growth factor receptor bound protein 2. | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | 0.556 |
GRB2 | KRAS | ENSNLEP00000040743 | ENSNLEP00000006371 | Growth factor receptor bound protein 2. | KRAS proto-oncogene, GTPase. | 0.760 |
GRB2 | M3ZBW0_NOMLE | ENSNLEP00000040743 | ENSNLEP00000024197 | Growth factor receptor bound protein 2. | SH2 domain-containing protein. | 0.658 |
GRB2 | NRAS | ENSNLEP00000040743 | ENSNLEP00000040445 | Growth factor receptor bound protein 2. | NRAS proto-oncogene, GTPase. | 0.638 |
GRB2 | PDGFB | ENSNLEP00000040743 | ENSNLEP00000018484 | Growth factor receptor bound protein 2. | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.459 |
GRB2 | PIK3CA | ENSNLEP00000040743 | ENSNLEP00000006936 | Growth factor receptor bound protein 2. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.859 |
GRB2 | PIK3R1 | ENSNLEP00000040743 | ENSNLEP00000031935 | Growth factor receptor bound protein 2. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.986 |
GRB2 | STAT3 | ENSNLEP00000040743 | ENSNLEP00000014018 | Growth factor receptor bound protein 2. | Signal transducer and activator of transcription. | 0.644 |
KIT | CSF1 | ENSNLEP00000010174 | ENSNLEP00000004199 | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | 0.974 |
KIT | GRB2 | ENSNLEP00000010174 | ENSNLEP00000040743 | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Growth factor receptor bound protein 2. | 0.997 |
KIT | KITLG | ENSNLEP00000010174 | ENSNLEP00000006667 | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | 0.999 |
KIT | KRAS | ENSNLEP00000010174 | ENSNLEP00000006371 | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | KRAS proto-oncogene, GTPase. | 0.970 |
KIT | M3ZBW0_NOMLE | ENSNLEP00000010174 | ENSNLEP00000024197 | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | SH2 domain-containing protein. | 0.964 |