Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PRKXProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (318 aa)    
Predicted Functional Partners:
PRKAR1A
Protein kinase cAMP-dependent type I regulatory subunit alpha.
 
 
 0.969
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
 
 
 0.874
PRKAR2A
Protein kinase cAMP-dependent type II regulatory subunit alpha.
 
 
 0.850
PRKAR1B
Protein kinase cAMP-dependent type I regulatory subunit beta.
   
 0.828
G1RZK2_NOMLE
Cyclic nucleotide-binding domain-containing protein.
   
 0.828
ENSNLEP00000046477
Uncharacterized protein.
   
 0.828
MAPKAPK3
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
   
 0.806
AKAP1
A-kinase anchoring protein 1.
    
 0.671
SUFU
Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]
    
 0.657
STK36
Serine/threonine kinase 36.
    
  0.647
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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