| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT3 | CDKN1B | ENSNLEP00000023896 | ENSNLEP00000024488 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Uncharacterized protein. | 0.981 |
| AKT3 | CREBBP | ENSNLEP00000023896 | ENSNLEP00000011912 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | CREB binding protein. | 0.409 |
| AKT3 | EP300 | ENSNLEP00000023896 | ENSNLEP00000035934 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | E1A binding protein p300. | 0.609 |
| AKT3 | PTEN | ENSNLEP00000023896 | ENSNLEP00000014741 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.781 |
| AKT3 | SIRT1 | ENSNLEP00000023896 | ENSNLEP00000014593 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Sirtuin 1. | 0.570 |
| AKT3 | TP53 | ENSNLEP00000023896 | ENSNLEP00000011861 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.913 |
| ATR | CHEK1 | ENSNLEP00000025629 | ENSNLEP00000040376 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Checkpoint kinase 1. | 0.999 |
| ATR | CHEK2 | ENSNLEP00000025629 | ENSNLEP00000002824 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Checkpoint kinase 2. | 0.991 |
| ATR | TP53 | ENSNLEP00000025629 | ENSNLEP00000011861 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.921 |
| CDKN1B | AKT3 | ENSNLEP00000024488 | ENSNLEP00000023896 | Uncharacterized protein. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.981 |
| CDKN1B | CHEK2 | ENSNLEP00000024488 | ENSNLEP00000002824 | Uncharacterized protein. | Checkpoint kinase 2. | 0.486 |
| CDKN1B | CREBBP | ENSNLEP00000024488 | ENSNLEP00000011912 | Uncharacterized protein. | CREB binding protein. | 0.782 |
| CDKN1B | EP300 | ENSNLEP00000024488 | ENSNLEP00000035934 | Uncharacterized protein. | E1A binding protein p300. | 0.781 |
| CDKN1B | PTEN | ENSNLEP00000024488 | ENSNLEP00000014741 | Uncharacterized protein. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.541 |
| CDKN1B | SIRT1 | ENSNLEP00000024488 | ENSNLEP00000014593 | Uncharacterized protein. | Sirtuin 1. | 0.412 |
| CDKN1B | TP53 | ENSNLEP00000024488 | ENSNLEP00000011861 | Uncharacterized protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.931 |
| CHEK1 | ATR | ENSNLEP00000040376 | ENSNLEP00000025629 | Checkpoint kinase 1. | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.999 |
| CHEK1 | CHEK2 | ENSNLEP00000040376 | ENSNLEP00000002824 | Checkpoint kinase 1. | Checkpoint kinase 2. | 0.989 |
| CHEK1 | TP53 | ENSNLEP00000040376 | ENSNLEP00000011861 | Checkpoint kinase 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.939 |
| CHEK1 | USP7 | ENSNLEP00000040376 | ENSNLEP00000012316 | Checkpoint kinase 1. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.941 |
