STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (535 aa)    
Predicted Functional Partners:
SIX2
SIX homeobox 2.
   
 
 0.718
ARL13A
ADP ribosylation factor like GTPase 13A.
      
 0.700
TNFSF18
Tumor necrosis factor ligand 2A.
      
 0.675
HSPB7
SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.
   
  
 0.673
SIX1
SIX homeobox 1.
   
 
 0.635
ATM
Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]
     
 0.608
SIX6
SIX homeobox 6.
   
 
 0.581
EYA2
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
  
  
 
0.571
G1QP80_NOMLE
Uncharacterized protein.
   
 
 0.568
H2AX
Histone H2A; Belongs to the histone H2A family.
    
 0.566
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.