STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1218 aa)    
Predicted Functional Partners:
SYK
Tyrosine-protein kinase.
   
 0.989
BTK
Tyrosine-protein kinase.
   
 0.961
SRC
Tyrosine-protein kinase.
   
 0.960
RAC2
Rac family small GTPase 2.
   
 0.953
LCP2
Lymphocyte cytosolic protein 2.
   
 0.949
GRAP2
GRB2 related adaptor protein 2.
    
 0.941
EGFR
Receptor protein-tyrosine kinase.
    
 0.936
ENSNLEP00000043688
Uncharacterized protein.
   
 0.929
FYN
Tyrosine-protein kinase.
   
0.925
YES1
Tyrosine-protein kinase.
   
 0.906
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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