| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASP8 | FADD | ENSNLEP00000040588 | ENSNLEP00000012731 | Caspase 8; Belongs to the peptidase C14A family. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.999 |
| CASP8 | IKBKB | ENSNLEP00000040588 | ENSNLEP00000015614 | Caspase 8; Belongs to the peptidase C14A family. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.828 |
| CASP8 | IKBKG | ENSNLEP00000040588 | ENSNLEP00000017384 | Caspase 8; Belongs to the peptidase C14A family. | NEMO domain-containing protein. | 0.739 |
| CASP8 | RIPK1 | ENSNLEP00000040588 | ENSNLEP00000013466 | Caspase 8; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 1. | 0.999 |
| CASP8 | RIPK3 | ENSNLEP00000040588 | ENSNLEP00000018788 | Caspase 8; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 3. | 0.998 |
| CASP8 | TNFRSF1A | ENSNLEP00000040588 | ENSNLEP00000029736 | Caspase 8; Belongs to the peptidase C14A family. | TNF receptor superfamily member 1A. | 0.876 |
| CASP8 | TRADD | ENSNLEP00000040588 | ENSNLEP00000005236 | Caspase 8; Belongs to the peptidase C14A family. | TNFRSF1A associated via death domain. | 0.998 |
| CASP8 | TRAF2 | ENSNLEP00000040588 | ENSNLEP00000010527 | Caspase 8; Belongs to the peptidase C14A family. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.975 |
| FADD | CASP8 | ENSNLEP00000012731 | ENSNLEP00000040588 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Caspase 8; Belongs to the peptidase C14A family. | 0.999 |
| FADD | IKBKB | ENSNLEP00000012731 | ENSNLEP00000015614 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.540 |
| FADD | IKBKG | ENSNLEP00000012731 | ENSNLEP00000017384 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | NEMO domain-containing protein. | 0.755 |
| FADD | RIPK1 | ENSNLEP00000012731 | ENSNLEP00000013466 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Receptor interacting serine/threonine kinase 1. | 0.999 |
| FADD | RIPK3 | ENSNLEP00000012731 | ENSNLEP00000018788 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Receptor interacting serine/threonine kinase 3. | 0.995 |
| FADD | TAB2 | ENSNLEP00000012731 | ENSNLEP00000018580 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. | 0.478 |
| FADD | TNFRSF1A | ENSNLEP00000012731 | ENSNLEP00000029736 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNF receptor superfamily member 1A. | 0.998 |
| FADD | TRADD | ENSNLEP00000012731 | ENSNLEP00000005236 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNFRSF1A associated via death domain. | 0.999 |
| FADD | TRAF2 | ENSNLEP00000012731 | ENSNLEP00000010527 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.994 |
| IKBKB | CASP8 | ENSNLEP00000015614 | ENSNLEP00000040588 | Inhibitor of nuclear factor kappa B kinase subunit beta. | Caspase 8; Belongs to the peptidase C14A family. | 0.828 |
| IKBKB | FADD | ENSNLEP00000015614 | ENSNLEP00000012731 | Inhibitor of nuclear factor kappa B kinase subunit beta. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.540 |
| IKBKB | IKBKG | ENSNLEP00000015614 | ENSNLEP00000017384 | Inhibitor of nuclear factor kappa B kinase subunit beta. | NEMO domain-containing protein. | 0.999 |
