| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSNLEP00000041707 | HERC2 | ENSNLEP00000041707 | ENSNLEP00000012856 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | HECT and RLD domain containing E3 ubiquitin protein ligase 2. | 0.633 |
| ENSNLEP00000041707 | MDC1 | ENSNLEP00000041707 | ENSNLEP00000006466 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Mediator of DNA damage checkpoint 1. | 0.603 |
| ENSNLEP00000041707 | NBN | ENSNLEP00000041707 | ENSNLEP00000029664 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.487 |
| ENSNLEP00000041707 | PAXIP1 | ENSNLEP00000041707 | ENSNLEP00000012860 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | PAX interacting protein 1. | 0.540 |
| ENSNLEP00000041707 | RNF8 | ENSNLEP00000041707 | ENSNLEP00000013584 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.893 |
| ENSNLEP00000041707 | TP53BP1 | ENSNLEP00000041707 | ENSNLEP00000006165 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Tumor protein p53 binding protein 1. | 0.621 |
| ENSNLEP00000041707 | UBE2E2 | ENSNLEP00000041707 | ENSNLEP00000004290 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. | 0.432 |
| ENSNLEP00000042204 | HERC2 | ENSNLEP00000042204 | ENSNLEP00000012856 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | HECT and RLD domain containing E3 ubiquitin protein ligase 2. | 0.633 |
| ENSNLEP00000042204 | MDC1 | ENSNLEP00000042204 | ENSNLEP00000006466 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Mediator of DNA damage checkpoint 1. | 0.603 |
| ENSNLEP00000042204 | NBN | ENSNLEP00000042204 | ENSNLEP00000029664 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.487 |
| ENSNLEP00000042204 | PAXIP1 | ENSNLEP00000042204 | ENSNLEP00000012860 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | PAX interacting protein 1. | 0.540 |
| ENSNLEP00000042204 | RNF8 | ENSNLEP00000042204 | ENSNLEP00000013584 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.893 |
| ENSNLEP00000042204 | TP53BP1 | ENSNLEP00000042204 | ENSNLEP00000006165 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Tumor protein p53 binding protein 1. | 0.621 |
| ENSNLEP00000042204 | UBE2E2 | ENSNLEP00000042204 | ENSNLEP00000004290 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. | 0.432 |
| H2AX | MDC1 | ENSNLEP00000038777 | ENSNLEP00000006466 | Histone H2A; Belongs to the histone H2A family. | Mediator of DNA damage checkpoint 1. | 0.977 |
| H2AX | NBN | ENSNLEP00000038777 | ENSNLEP00000029664 | Histone H2A; Belongs to the histone H2A family. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.961 |
| H2AX | PAXIP1 | ENSNLEP00000038777 | ENSNLEP00000012860 | Histone H2A; Belongs to the histone H2A family. | PAX interacting protein 1. | 0.712 |
| H2AX | RNF8 | ENSNLEP00000038777 | ENSNLEP00000013584 | Histone H2A; Belongs to the histone H2A family. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.929 |
| H2AX | TP53BP1 | ENSNLEP00000038777 | ENSNLEP00000006165 | Histone H2A; Belongs to the histone H2A family. | Tumor protein p53 binding protein 1. | 0.980 |
| HERC2 | ENSNLEP00000041707 | ENSNLEP00000012856 | ENSNLEP00000041707 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.633 |
