STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
COTL1ADF-H domain-containing protein. (73 aa)    
Predicted Functional Partners:
GPR17
G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family.
      
 0.706
ALOX5
Arachidonate 5-lipoxygenase.
    
 
 0.679
SP1
Sp1 transcription factor.
      
 0.611
ALOX12B
Arachidonate 12-lipoxygenase, 12R type.
    
 
 0.581
ALOXE3
Arachidonate lipoxygenase 3.
    
 
 0.581
GAK
Cyclin G associated kinase.
   
 
 0.580
CAPZB
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
   
 0.486
ACTR2
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
   
 
 0.484
CAP2
Adenylyl cyclase-associated protein; Belongs to the CAP family.
   
 
 0.479
CAP1
Adenylyl cyclase-associated protein; Belongs to the CAP family.
   
 
 0.479
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.