STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)    
Predicted Functional Partners:
HCRTR1
Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family.
   
 0.999
HCRTR2
Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family.
   
 0.998
PMCH
Pro-melanin concentrating hormone.
   
 
 0.920
ENSNLEP00000027720
Uncharacterized protein.
   
 
 0.920
NPS
Neuropeptide S.
     
 0.806
HLA-DQB1
Major histocompatibility complex, class II, DQ beta 1.
    
 
 0.792
GHRL
Ghrelin and obestatin prepropeptide.
     
 0.783
NTS
Neurotensin.
     
 0.763
TAC1
Tachykinin precursor 1.
     
 0.738
MCHR2
Melanin concentrating hormone receptor 2; Belongs to the G-protein coupled receptor 1 family.
    
 0.731
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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