Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)    
Predicted Functional Partners:
IL2
Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.
    
 0.999
IL2RB
Interleukin 2 receptor subunit beta.
   
 0.997
M3ZBW0_NOMLE
SH2 domain-containing protein.
   
 0.991
JAK1
Tyrosine-protein kinase.
   
 
 0.987
IL2RG
Fibronectin type-III domain-containing protein.
   
 0.986
JAK3
Tyrosine-protein kinase.
   
 
 0.969
IL7R
Interleukin 7 receptor.
     
 0.957
IL15RA
Sushi domain-containing protein.
     
 0.948
IL21R
Interleukin 21 receptor.
   
 
 0.944
FOXP3
Forkhead box P3.
   
 0.934
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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