Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
IL4RInterleukin 4 receptor. (810 aa)    
Predicted Functional Partners:
IL4
Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.
  
 
 0.998
IL13
Interleukin 13.
  
 
 0.997
STAT6
Signal transducer and activator of transcription.
   
 0.995
IL2RG
Fibronectin type-III domain-containing protein.
    
 0.992
JAK1
Tyrosine-protein kinase.
    
 0.991
IL13RA1
Interleukin 13 receptor subunit alpha 1.
    
 0.986
JAK2
Tyrosine-protein kinase.
    
 0.975
JAK3
Tyrosine-protein kinase.
    
 0.971
TYK2
Tyrosine-protein kinase.
    
 0.954
IL7R
Interleukin 7 receptor.
    
 0.952
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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