STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TICRRTOPBP1 interacting checkpoint and replication regulator. (1829 aa)    
Predicted Functional Partners:
TOPBP1
DNA topoisomerase II binding protein 1.
    
 
 0.991
CDC45
Cell division cycle 45.
   
  
 0.861
MTBP
MDM2 binding protein.
   
 0.840
MCM10
Minichromosome maintenance 10 replication initiation factor.
   
  
 0.824
RECQL4
RecQ like helicase 4.
  
 
 0.787
MCM4
DNA helicase; Belongs to the MCM family.
   
  
 0.779
EXO1
Exonuclease 1.
  
 
 0.770
GINS4
DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.
   
 
 0.725
TBL3
Transducin beta like 3.
   
 
 0.725
GINS3
GINS complex subunit 3.
   
  
 0.725
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.