STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TICAM2Toll like receptor adaptor molecule 2. (234 aa)    
Predicted Functional Partners:
TLR4
Toll like receptor 4; Belongs to the Toll-like receptor family.
   
 0.991
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.975
TICAM1
TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.
    
0.973
TLR2
Toll-like receptor.
   
 0.968
RIPK1
Receptor interacting serine/threonine kinase 1.
   
 0.957
G1R620_NOMLE
TIR domain-containing protein.
   
 0.941
TLR3
Toll like receptor 3; Belongs to the Toll-like receptor family.
   
 0.856
TMED2
Transmembrane p24 trafficking protein 2.
   
 0.804
ENSNLEP00000039759
GOLD domain-containing protein.
   
 0.804
IRF3
IRF tryptophan pentad repeat domain-containing protein.
    
 0.781
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.