Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ACTA2Actin alpha 2, smooth muscle. (418 aa)    
Predicted Functional Partners:
ACTG2
Actin gamma 2, smooth muscle.
   
 
 0.798
TNNT2
Uncharacterized protein.
   
 
 0.724
TNNI3
Troponin I3, cardiac type.
   
 
 0.709
MYSM1
Myb like, SWIRM and MPN domains 1.
   
 0.709
ARPC2
Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
   
 0.686
ARPC1B
WD_REPEATS_REGION domain-containing protein.
   
 0.680
TNNC1
Troponin C1, slow skeletal and cardiac type.
   
 0.672
MYO1C
Myosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
    
 0.667
ACTBL2
Actin beta like 2.
   
   0.645
VCL
Vinculin.
   
 0.644
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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