Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EPORErythropoietin receptor; Receptor for erythropoietin. (520 aa)    
Predicted Functional Partners:
JAK2
Tyrosine-protein kinase.
    
 0.999
EPO
Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.
    
 0.992
M3ZBW0_NOMLE
SH2 domain-containing protein.
    
 0.989
JAK3
Tyrosine-protein kinase.
    
 0.983
JAK1
Tyrosine-protein kinase.
    
 0.964
STAT3
Signal transducer and activator of transcription.
    
 0.955
CSF3R
Colony stimulating factor 3 receptor.
     
 0.928
GRB2
Growth factor receptor bound protein 2.
    
 0.916
GHR
Growth hormone receptor.
   
 
 0.912
LEPR
Leptin receptor.
     
 0.909
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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