| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APEX1 | LIG1 | ENSNLEP00000013259 | ENSNLEP00000039127 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA ligase. | 0.959 |
| APEX1 | LIG3 | ENSNLEP00000013259 | ENSNLEP00000035608 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA ligase. | 0.731 |
| APEX1 | NEIL1 | ENSNLEP00000013259 | ENSNLEP00000016102 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | FPG_CAT domain-containing protein. | 0.500 |
| APEX1 | PARP1 | ENSNLEP00000013259 | ENSNLEP00000016881 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.765 |
| APEX1 | PARP2 | ENSNLEP00000013259 | ENSNLEP00000013109 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Poly [ADP-ribose] polymerase. | 0.611 |
| APEX1 | PNKP | ENSNLEP00000013259 | ENSNLEP00000033964 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | FHA_2 domain-containing protein. | 0.734 |
| APEX1 | POLB | ENSNLEP00000013259 | ENSNLEP00000015641 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.990 |
| APEX1 | TDP1 | ENSNLEP00000013259 | ENSNLEP00000040013 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Tyrosyl-DNA phosphodiesterase 1. | 0.731 |
| APEX1 | XRCC1 | ENSNLEP00000013259 | ENSNLEP00000001912 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | X-ray repair cross complementing 1. | 0.858 |
| LIG1 | APEX1 | ENSNLEP00000039127 | ENSNLEP00000013259 | DNA ligase. | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 0.959 |
| LIG1 | LIG3 | ENSNLEP00000039127 | ENSNLEP00000035608 | DNA ligase. | DNA ligase. | 0.566 |
| LIG1 | NEIL1 | ENSNLEP00000039127 | ENSNLEP00000016102 | DNA ligase. | FPG_CAT domain-containing protein. | 0.534 |
| LIG1 | PARP1 | ENSNLEP00000039127 | ENSNLEP00000016881 | DNA ligase. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.518 |
| LIG1 | PARP2 | ENSNLEP00000039127 | ENSNLEP00000013109 | DNA ligase. | Poly [ADP-ribose] polymerase. | 0.492 |
| LIG1 | PNKP | ENSNLEP00000039127 | ENSNLEP00000033964 | DNA ligase. | FHA_2 domain-containing protein. | 0.593 |
| LIG1 | POLB | ENSNLEP00000039127 | ENSNLEP00000015641 | DNA ligase. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.979 |
| LIG1 | TDP1 | ENSNLEP00000039127 | ENSNLEP00000040013 | DNA ligase. | Tyrosyl-DNA phosphodiesterase 1. | 0.614 |
| LIG1 | XRCC1 | ENSNLEP00000039127 | ENSNLEP00000001912 | DNA ligase. | X-ray repair cross complementing 1. | 0.943 |
| LIG3 | APEX1 | ENSNLEP00000035608 | ENSNLEP00000013259 | DNA ligase. | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 0.731 |
| LIG3 | LIG1 | ENSNLEP00000035608 | ENSNLEP00000039127 | DNA ligase. | DNA ligase. | 0.566 |
