LPXN protein (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

LPXN

Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (387 aa)

Predicted Functional Partners:

VCL

0.948

PARVA

0.932

PTK2B

0.928

TLN1

0.926

SRC

0.904

CRK

0.867

PARVB

0.864

BCAR1

0.859

CSK

0.852

YES1

0.848

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR1	CRK	ENSNLEP00000041451	ENSNLEP00000000851	BCAR1 scaffold protein, Cas family member.	Uncharacterized protein.	0.998
BCAR1	CSK	ENSNLEP00000041451	ENSNLEP00000017774	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.468
BCAR1	LPXN	ENSNLEP00000041451	ENSNLEP00000015809	BCAR1 scaffold protein, Cas family member.	Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN).	0.859
BCAR1	PTK2B	ENSNLEP00000041451	ENSNLEP00000019773	BCAR1 scaffold protein, Cas family member.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.996
BCAR1	SRC	ENSNLEP00000041451	ENSNLEP00000048569	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.998
BCAR1	TLN1	ENSNLEP00000041451	ENSNLEP00000034100	BCAR1 scaffold protein, Cas family member.	Talin 1.	0.705
BCAR1	VCL	ENSNLEP00000041451	ENSNLEP00000041781	BCAR1 scaffold protein, Cas family member.	Vinculin.	0.925
BCAR1	YES1	ENSNLEP00000041451	ENSNLEP00000008358	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.926
CRK	BCAR1	ENSNLEP00000000851	ENSNLEP00000041451	Uncharacterized protein.	BCAR1 scaffold protein, Cas family member.	0.998
CRK	CSK	ENSNLEP00000000851	ENSNLEP00000017774	Uncharacterized protein.	Tyrosine-protein kinase.	0.462
CRK	LPXN	ENSNLEP00000000851	ENSNLEP00000015809	Uncharacterized protein.	Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN).	0.867
CRK	PTK2B	ENSNLEP00000000851	ENSNLEP00000019773	Uncharacterized protein.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.980
CRK	SRC	ENSNLEP00000000851	ENSNLEP00000048569	Uncharacterized protein.	Tyrosine-protein kinase.	0.994
CRK	TLN1	ENSNLEP00000000851	ENSNLEP00000034100	Uncharacterized protein.	Talin 1.	0.483
CRK	VCL	ENSNLEP00000000851	ENSNLEP00000041781	Uncharacterized protein.	Vinculin.	0.514
CRK	YES1	ENSNLEP00000000851	ENSNLEP00000008358	Uncharacterized protein.	Tyrosine-protein kinase.	0.869
CSK	BCAR1	ENSNLEP00000017774	ENSNLEP00000041451	Tyrosine-protein kinase.	BCAR1 scaffold protein, Cas family member.	0.468
CSK	CRK	ENSNLEP00000017774	ENSNLEP00000000851	Tyrosine-protein kinase.	Uncharacterized protein.	0.462
CSK	LPXN	ENSNLEP00000017774	ENSNLEP00000015809	Tyrosine-protein kinase.	Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN).	0.852
CSK	PTK2B	ENSNLEP00000017774	ENSNLEP00000019773	Tyrosine-protein kinase.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.525

page 1 of 5

Server load: low (16%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About