| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATM | DCLRE1C | ENSNLEP00000008823 | ENSNLEP00000028695 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Uncharacterized protein. | 0.860 |
| ATM | H2AX | ENSNLEP00000008823 | ENSNLEP00000038777 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Histone H2A; Belongs to the histone H2A family. | 0.982 |
| ATM | LIG4 | ENSNLEP00000008823 | ENSNLEP00000009615 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | DNA ligase. | 0.892 |
| ATM | LOC100580673 | ENSNLEP00000008823 | ENSNLEP00000043734 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Ku domain-containing protein. | 0.802 |
| ATM | NHEJ1 | ENSNLEP00000008823 | ENSNLEP00000011039 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Non-homologous end joining factor 1. | 0.753 |
| ATM | PRKDC | ENSNLEP00000008823 | ENSNLEP00000016119 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Protein kinase, DNA-activated, catalytic subunit. | 0.935 |
| ATM | XRCC5 | ENSNLEP00000008823 | ENSNLEP00000008862 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.976 |
| ATM | XRCC6 | ENSNLEP00000008823 | ENSNLEP00000018935 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | X-ray repair cross complementing 6. | 0.867 |
| DCLRE1C | ATM | ENSNLEP00000028695 | ENSNLEP00000008823 | Uncharacterized protein. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.860 |
| DCLRE1C | LIG4 | ENSNLEP00000028695 | ENSNLEP00000009615 | Uncharacterized protein. | DNA ligase. | 0.975 |
| DCLRE1C | LOC100580673 | ENSNLEP00000028695 | ENSNLEP00000043734 | Uncharacterized protein. | Ku domain-containing protein. | 0.846 |
| DCLRE1C | NHEJ1 | ENSNLEP00000028695 | ENSNLEP00000011039 | Uncharacterized protein. | Non-homologous end joining factor 1. | 0.907 |
| DCLRE1C | POLL | ENSNLEP00000028695 | ENSNLEP00000018097 | Uncharacterized protein. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.845 |
| DCLRE1C | PRKDC | ENSNLEP00000028695 | ENSNLEP00000016119 | Uncharacterized protein. | Protein kinase, DNA-activated, catalytic subunit. | 0.987 |
| DCLRE1C | XRCC5 | ENSNLEP00000028695 | ENSNLEP00000008862 | Uncharacterized protein. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.985 |
| DCLRE1C | XRCC6 | ENSNLEP00000028695 | ENSNLEP00000018935 | Uncharacterized protein. | X-ray repair cross complementing 6. | 0.897 |
| H2AX | ATM | ENSNLEP00000038777 | ENSNLEP00000008823 | Histone H2A; Belongs to the histone H2A family. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.982 |
| H2AX | LIG4 | ENSNLEP00000038777 | ENSNLEP00000009615 | Histone H2A; Belongs to the histone H2A family. | DNA ligase. | 0.402 |
| H2AX | LOC100580673 | ENSNLEP00000038777 | ENSNLEP00000043734 | Histone H2A; Belongs to the histone H2A family. | Ku domain-containing protein. | 0.880 |
| H2AX | NHEJ1 | ENSNLEP00000038777 | ENSNLEP00000011039 | Histone H2A; Belongs to the histone H2A family. | Non-homologous end joining factor 1. | 0.460 |
