Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CSPG4Chondroitin sulfate proteoglycan 4. (2170 aa)    
Predicted Functional Partners:
GRIP1
Glutamate receptor interacting protein 1.
    
 0.825
PDGFRA
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
   
 
 0.700
PLP1
Proteolipid protein 1.
      
 0.697
GFAP
IF rod domain-containing protein; Belongs to the intermediate filament family.
      
 0.692
NECTIN3
Nectin cell adhesion molecule 3.
   
  
 0.691
FAT4
FAT atypical cadherin 4.
   
  
 0.676
FZD7
Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.
      
 0.641
RHOU
Ras homolog family member U.
   
 
 0.639
OLIG2
Oligodendrocyte transcription factor 2.
   
  
 0.629
SDC3
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
  
  
 0.610
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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