| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGF | IGF1 | ENSNLEP00000020085 | ENSNLEP00000045069 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | IlGF domain-containing protein. | 0.960 |
| EGF | IGF1R | ENSNLEP00000020085 | ENSNLEP00000044618 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Tyrosine-protein kinase receptor. | 0.951 |
| EGF | INS-IGF2 | ENSNLEP00000020085 | ENSNLEP00000016293 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.980 |
| EGF | INSR | ENSNLEP00000020085 | ENSNLEP00000000477 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Insulin receptor. | 0.960 |
| EGF | INSRR | ENSNLEP00000020085 | ENSNLEP00000015550 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Tyrosine-protein kinase receptor. | 0.794 |
| GHRL | IGF1 | ENSNLEP00000005413 | ENSNLEP00000045069 | Ghrelin and obestatin prepropeptide. | IlGF domain-containing protein. | 0.909 |
| GHRL | INS-IGF2 | ENSNLEP00000005413 | ENSNLEP00000016293 | Ghrelin and obestatin prepropeptide. | INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.948 |
| IDE | INS-IGF2 | ENSNLEP00000041630 | ENSNLEP00000016293 | Insulin degrading enzyme. | INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.971 |
| IGF1 | EGF | ENSNLEP00000045069 | ENSNLEP00000020085 | IlGF domain-containing protein. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.960 |
| IGF1 | GHRL | ENSNLEP00000045069 | ENSNLEP00000005413 | IlGF domain-containing protein. | Ghrelin and obestatin prepropeptide. | 0.909 |
| IGF1 | IGF1R | ENSNLEP00000045069 | ENSNLEP00000044618 | IlGF domain-containing protein. | Tyrosine-protein kinase receptor. | 0.999 |
| IGF1 | INS-IGF2 | ENSNLEP00000045069 | ENSNLEP00000016293 | IlGF domain-containing protein. | INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.973 |
| IGF1 | INSR | ENSNLEP00000045069 | ENSNLEP00000000477 | IlGF domain-containing protein. | Insulin receptor. | 0.996 |
| IGF1 | INSRR | ENSNLEP00000045069 | ENSNLEP00000015550 | IlGF domain-containing protein. | Tyrosine-protein kinase receptor. | 0.922 |
| IGF1 | IRS1 | ENSNLEP00000045069 | ENSNLEP00000035157 | IlGF domain-containing protein. | Insulin receptor substrate 1. | 0.826 |
| IGF1 | IRS2 | ENSNLEP00000045069 | ENSNLEP00000046467 | IlGF domain-containing protein. | Insulin receptor substrate 2. | 0.734 |
| IGF1 | IRS4 | ENSNLEP00000045069 | ENSNLEP00000022231 | IlGF domain-containing protein. | Insulin receptor substrate 4. | 0.535 |
| IGF1R | EGF | ENSNLEP00000044618 | ENSNLEP00000020085 | Tyrosine-protein kinase receptor. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.951 |
| IGF1R | IGF1 | ENSNLEP00000044618 | ENSNLEP00000045069 | Tyrosine-protein kinase receptor. | IlGF domain-containing protein. | 0.999 |
| IGF1R | INS-IGF2 | ENSNLEP00000044618 | ENSNLEP00000016293 | Tyrosine-protein kinase receptor. | INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.992 |
