| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACACA | PPARG | ENSNLEP00000003141 | ENSNLEP00000037002 | Acetyl-CoA carboxylase alpha. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.502 |
| ACACA | SCD | ENSNLEP00000003141 | ENSNLEP00000017948 | Acetyl-CoA carboxylase alpha. | Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. | 0.779 |
| ACACA | SREBF1 | ENSNLEP00000003141 | ENSNLEP00000031265 | Acetyl-CoA carboxylase alpha. | Sterol regulatory element binding transcription factor 1. | 0.883 |
| ACACA | SREBF2 | ENSNLEP00000003141 | ENSNLEP00000018990 | Acetyl-CoA carboxylase alpha. | Sterol regulatory element binding transcription factor 2. | 0.560 |
| EP300 | FBXW7 | ENSNLEP00000035934 | ENSNLEP00000007135 | E1A binding protein p300. | F-box and WD repeat domain containing 7. | 0.539 |
| EP300 | MED15 | ENSNLEP00000035934 | ENSNLEP00000009639 | E1A binding protein p300. | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.552 |
| EP300 | PPARG | ENSNLEP00000035934 | ENSNLEP00000037002 | E1A binding protein p300. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.976 |
| EP300 | SREBF1 | ENSNLEP00000035934 | ENSNLEP00000031265 | E1A binding protein p300. | Sterol regulatory element binding transcription factor 1. | 0.916 |
| EP300 | SREBF2 | ENSNLEP00000035934 | ENSNLEP00000018990 | E1A binding protein p300. | Sterol regulatory element binding transcription factor 2. | 0.568 |
| FBXW7 | EP300 | ENSNLEP00000007135 | ENSNLEP00000035934 | F-box and WD repeat domain containing 7. | E1A binding protein p300. | 0.539 |
| FBXW7 | SREBF1 | ENSNLEP00000007135 | ENSNLEP00000031265 | F-box and WD repeat domain containing 7. | Sterol regulatory element binding transcription factor 1. | 0.891 |
| FBXW7 | SREBF2 | ENSNLEP00000007135 | ENSNLEP00000018990 | F-box and WD repeat domain containing 7. | Sterol regulatory element binding transcription factor 2. | 0.460 |
| MED15 | EP300 | ENSNLEP00000009639 | ENSNLEP00000035934 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | E1A binding protein p300. | 0.552 |
| MED15 | PPARGC1B | ENSNLEP00000009639 | ENSNLEP00000012424 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | PPARG coactivator 1 beta. | 0.569 |
| MED15 | SREBF1 | ENSNLEP00000009639 | ENSNLEP00000031265 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Sterol regulatory element binding transcription factor 1. | 0.875 |
| MED15 | SREBF2 | ENSNLEP00000009639 | ENSNLEP00000018990 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Sterol regulatory element binding transcription factor 2. | 0.684 |
| NPC1 | SREBF1 | ENSNLEP00000008199 | ENSNLEP00000031265 | NPC intracellular cholesterol transporter 1. | Sterol regulatory element binding transcription factor 1. | 0.846 |
| NPC1 | SREBF2 | ENSNLEP00000008199 | ENSNLEP00000018990 | NPC intracellular cholesterol transporter 1. | Sterol regulatory element binding transcription factor 2. | 0.894 |
| PPARG | ACACA | ENSNLEP00000037002 | ENSNLEP00000003141 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | Acetyl-CoA carboxylase alpha. | 0.502 |
| PPARG | EP300 | ENSNLEP00000037002 | ENSNLEP00000035934 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | E1A binding protein p300. | 0.976 |